Description
Clonidine Hydrochloride Tablets
Healthy Inc is a specialized global supplier and exporter of centrally acting antihypertensives. We provide high-purity Clonidine Hydrochloride Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Sympathetic Brake” agent is a top export to addiction recovery centers, psychiatric institutes, and government health tenders in Africa, LATAM, and Southeast Asia, recognized for its dual utility in managing severe hypertension and opioid/alcohol withdrawal syndromes.
Product Overview
This formulation contains Clonidine Hydrochloride, an imidazoline derivative that acts as a central alpha-2 agonist.
The “Sympathetic Regulator” Specialist:
- Mechanism: Unlike beta-blockers or ACE inhibitors that act on the heart or vessels directly, Clonidine works in the Brainstem (Medulla Oblongata). It stimulates Alpha-2 adrenergic receptors, effectively tricking the brain into reducing the “Fight or Flight” (sympathetic) nervous system outflow.
- Result: This reduction in sympathetic tone leads to decreased heart rate, relaxation of blood vessels (vasodilation), and a significant drop in blood pressure.
- Withdrawal Management: By dampening the sympathetic overactivity (sweating, agitation, rapid heart rate) that occurs during withdrawal from opioids, alcohol, or nicotine, it serves as a critical palliative medication in detox protocols.
- ADHD Application: In extended-release forms, it is also used to treat Attention Deficit Hyperactivity Disorder (ADHD) by regulating norepinephrine levels in the prefrontal cortex.
Product Composition & Strength
We supply this product as Uncoated Tablets (Small, White). Note: Clonidine is extremely potent and dosed in micrograms (mcg), not milligrams.
| Active Ingredient | Strength (Metric) | Strength (Common) | Primary Role |
|---|---|---|---|
| Clonidine HCl USP/BP/IP | 100 mcg | 0.1 mg | Initiation / Mild Hypertension |
| Clonidine HCl USP/BP/IP | 200 mcg | 0.2 mg | Standard Maintenance |
| Clonidine HCl USP/BP/IP | 300 mcg | 0.3 mg | High Dose / Crisis Management |
| Excipients | Q.S. | Lactose / Corn Starch | Filler / Binder |
*Pack Sizes: Blister packs of 10s (Box of 10×10), 30s, or Bulk HDPE Jars of 1000s.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| CAS Number | 4205-90-7 |
| Dosage Form | Tablet (Uncoated) |
| Packaging | PVC-Alu Blister or Alu-Alu Blister |
| Storage | Store below 25°C. Keep in a dry place. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Content Uniformity (Critical): Since Clonidine is dosed in micrograms (a 100mcg tablet is 1/10th of a milligram), uneven mixing during manufacturing can be fatal. We employ high-precision geometric dilution and validated blending processes (RSD < 2%) to ensure every single tablet contains the exact therapeutic dose.
- Dissolution: Engineered for consistent release to prevent rapid spikes in plasma concentration which can cause excessive sedation or dry mouth.
Therapeutic Indications (Human Use)
Indicated for multiple cardiovascular and CNS conditions:
- Hypertension: Treatment of high blood pressure (often used when other drugs fail or for renal patients).
- Hypertensive Urgency: Rapid reduction of dangerously high blood pressure.
- Opioid/Alcohol Withdrawal: Relief of agitation, tremors, sweating, and tachycardia during detox.
- ADHD: Adjunctive therapy for hyperactivity and impulsivity.
- Menopausal Flushing: Reduction of hot flashes.
Dosage & Administration
Recommended Dosage (Strictly as per Physician):
- Route: Oral.
- Hypertension: Initially 0.1 mg (100 mcg) twice daily. Can be increased by 0.1 mg per week. Maximum dose usually 2.4 mg/day.
- Withdrawal Management: 0.1 mg to 0.2 mg every 4-6 hours as needed, monitoring blood pressure strictly.
- Administration: Can be taken with or without food. Best taken at bedtime to minimize daytime drowsiness.
Safety Warnings:
- Rebound Hypertension (DANGER): Do not stop abruptly. Sudden cessation can cause a rapid, life-threatening spike in blood pressure (“Overshoot Hypertension”), nervousness, and agitation. The dose must be tapered gradually over 2–4 days.
- Sedation & Drowsiness: Very common. Patients should not drive or operate machinery until they know how the drug affects them.
- Dry Mouth (Xerostomia): Occurs in many patients.
- Bradycardia: Can slow heart rate significantly. Use caution in patients with heart block.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
