Description
Digoxin Tablets
Healthy Inc is a specialized global supplier and exporter of high-potency cardiac glycosides. We provide high-purity Digoxin Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Narrow Therapeutic Index” agent is a top export to cardiology departments, geriatric care units, and government health tenders in Africa, LATAM, and Southeast Asia, serving as a critical inotropic agent for the management of chronic heart failure and atrial arrhythmias.
Product Overview
This formulation contains Digoxin, a purified cardiac glycoside extracted from the foxglove plant (Digitalis lanata).
The “Force & Rhythm” Specialist:
- Dual Mechanism:
- Positive Inotropic Effect (Strength): Digoxin inhibits the Na+/K+-ATPase pump in heart muscle cells. This leads to an accumulation of intracellular sodium, which in turn increases intracellular calcium. The result is a stronger, more forceful contraction of the failing heart muscle.
- Negative Chronotropic Effect (Rate): It increases vagal tone (parasympathetic activity), which slows down the electrical conduction through the AV node. This effectively controls the rapid heart rate seen in Atrial Fibrillation.
- Narrow Therapeutic Index: Digoxin is a potent drug where the difference between a therapeutic dose and a toxic dose is very small. Precision in manufacturing and dosing is non-negotiable.
Product Composition & Strength
We supply this product as Uncoated Tablets (Scored). Due to the potency (measured in micrograms), precise titration options are essential.
| Active Ingredient | Strength (Standard) | Target Patient |
|---|---|---|
| Digoxin USP/BP/IP | 0.0625 mg (62.5 mcg) | Pediatric / Severe Renal Failure |
| Digoxin USP/BP/IP | 0.125 mg (125 mcg) | Geriatric / Maintenance |
| Digoxin USP/BP/IP | 0.25 mg (250 mcg) | Standard Adult Dose |
| Excipients | Q.S. | Lactose / Maize Starch |
*Pack Sizes: Blister packs of 10s (Box of 10×10), 30s, or Bulk HDPE Jars of 1000s (Institutional Packs).
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Tablet (Oral) |
| Packaging | PVC-Alu Blister or Alu-Alu Blister |
| Storage | Store below 25°C. Protect from moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Micronization & Bioavailability: Digoxin has historically suffered from bioavailability issues due to poor water solubility. We utilize Micronized API (ultra-fine particle size) to ensure consistent dissolution rates that match the innovator profile (Lanoxin), preventing therapeutic failure.
- Content Uniformity (Critical): Since the dose is extremely low (micrograms), we employ advanced geometric blending and high-precision compression to ensure every tablet contains exactly the stated dose, preventing potentially fatal “hot spots” in a batch.
Therapeutic Indications (Human Use)
Indicated for the management of cardiac conditions:
- Heart Failure: To improve cardiac output and reduce hospitalization in patients with mild to moderate heart failure (usually added to ACE inhibitors/Diuretics).
- Atrial Fibrillation / Atrial Flutter: To control the ventricular response rate (slow down the heart rate).
Dosage & Administration
Recommended Dosage (Strictly as per Cardiologist):
- Route: Oral.
- Loading Dose (“Digitalization”): 0.75 mg to 1.5 mg given in divided doses over 24 hours (Hospital only).
- Maintenance Dose:
- Adults: 0.125 mg to 0.25 mg once daily.
- Elderly: 0.0625 mg once daily.
- Renal Adjustment (Mandatory): Digoxin is excreted largely unchanged by the kidneys. In renal impairment, the dose must be reduced drastically or the interval extended to avoid accumulation and toxicity.
Safety Warnings:
- Digoxin Toxicity: Symptoms include nausea, vomiting, confusion, and visual disturbances (yellow/green halos around lights). Requires immediate medical attention.
- Hypokalemia Interaction: Low potassium levels (often caused by Furosemide) significantly increase the risk of Digoxin toxicity. Potassium levels must be monitored.
- Heart Block: Contraindicated in patients with AV block (unless paced).
- Therapeutic Drug Monitoring (TDM): Serum digoxin levels should be monitored to ensure they remain within the safe range (0.5–2.0 ng/mL).
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
