Description
Glibenclamide (Glyburide) Tablets
Healthy Inc is a specialized global supplier and exporter of potent anti-diabetic agents. We provide high-purity Glibenclamide Tablets (also known as Glyburide), sourced from WHO–GMP certified solid dosage facilities. This “Insulin Secretagogue” is a top export to diabetic clinics, government healthcare tenders, and pharmacy chains in Africa, LATAM, and Southeast Asia, serving as a highly effective and cost-efficient second-generation sulfonylurea for Type 2 Diabetes management.
Product Overview
This formulation contains Glibenclamide, a potent second-generation sulfonylurea.
The “Pancreatic Stimulator” Specialist:
- Mechanism: Glibenclamide works by binding to specific sulfonylurea receptors on the surface of pancreatic beta cells. This blocks ATP-sensitive potassium channels, causing depolarization and the opening of calcium channels. The influx of calcium triggers the release of pre-formed insulin into the bloodstream.
- Potency: It is one of the most potent sulfonylureas available. A small dose (2.5 mg or 5 mg) can significantly lower blood glucose levels, making it highly effective for patients who are not overweight and still have residual pancreatic function.
- 24-Hour Control: While it has a short half-life, its biological effect persists for up to 24 hours, often allowing for once-daily dosing.
- Combination Therapy: Frequently co-prescribed with Metformin (which acts on the liver/muscle) to attack diabetes from two different angles (increasing secretion + decreasing resistance).
Product Composition & Strength
We supply this product as Uncoated Tablets (Scored). The tablet is usually white or pink and scored to allow for precise dose titration.
| Active Ingredient | Strength (Standard) | Role |
|---|---|---|
| Glibenclamide USP/BP | 1.25 mg | Geriatric / Renal Impairment |
| Glibenclamide USP/BP | 2.5 mg | Initial Dose / Mild Diabetes |
| Glibenclamide USP/BP | 5 mg | Standard Therapeutic Dose |
| Excipients | Q.S. | Lactose (Diluent) / Maize Starch |
*Pack Sizes: Blister packs of 10s (Box of 10×10), 28s, 30s, or Bulk HDPE Jars of 1000s/5000s (Hospital Packs).
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Tablet (Oral) |
| Packaging | PVC-Alu Blister or Bulk Jar |
| Storage | Store below 25°C. Protect from moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Micronization: Glibenclamide has poor water solubility. We utilize Micronized API technology to reduce particle size, significantly increasing the surface area and dissolution rate. This ensures predictable absorption and consistent bio-efficacy.
- Content Uniformity: As a high-potency drug (low mg dose), we employ high-shear blending to ensure even distribution of the API, preventing “hot spots” in the tablet batch that could cause dangerous hypoglycemia.
Therapeutic Indications (Human Use)
Indicated for the management of Type 2 Diabetes Mellitus:
- Monotherapy: For patients whose blood sugar cannot be controlled by diet and exercise alone.
- Combination Therapy: Used with Metformin or Thiazolidinediones when monotherapy fails.
- Note: Not effective for Type 1 Diabetes (where the pancreas produces no insulin).
Dosage & Administration
Recommended Dosage (Strictly as per Endocrinologist):
- Route: Oral.
- Starting Dose: 2.5 mg to 5 mg daily.
- Maintenance: Adjust by 2.5 mg increments weekly based on blood glucose monitoring. Maximum daily dose is usually 15 mg or 20 mg.
- Timing: MUST be taken with the first main meal of the day (Breakfast). Taking it on an empty stomach or skipping a meal after taking it creates a high risk of hypoglycemia.
Safety Warnings:
- Hypoglycemia (Low Blood Sugar): This is the most common and serious side effect. It is long-acting, so hypoglycemia can be prolonged and severe. Patients must carry glucose/sugar.
- Weight Gain: Insulin is an anabolic hormone; stimulating its release often leads to weight gain. Diet control is essential.
- Sulfa Allergy: Related to sulfonamides. Use with caution in allergic patients.
- Renal/Hepatic Failure: Contraindicated in severe kidney or liver disease as the drug can accumulate, leading to fatal hypoglycemia.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
