Description

Metformin Hydrochloride Tablets (500 mg / 850 mg / 1000 mg)

Healthy Inc is a premier global supplier of high-stability antidiabetic therapies. We provide premium Metformin Hydrochloride Tablets, available in Immediate-Release (IR) and Sustained-Release (SR/ER) profiles, manufactured in WHO–GMP certified specialized metabolic units. As the gold standard for glycemic control, this product is a cornerstone export for endocrinology clinics, public health programs, and Ministry of Health (MOH) tenders in Southeast Asia, Africa, and the Middle East.

Product Overview

Metformin is a biguanide antihyperglycemic agent. It is specifically engineered to improve glucose tolerance in patients with Type 2 Diabetes by lowering both basal and postprandial plasma glucose without stimulating insulin secretion, thereby avoiding the risk of hypoglycemia.

The “Metabolic Foundation” Specialist:

• Mechanism of Action: Metformin works via three primary pathways: (1) Reduction of hepatic glucose production by inhibiting gluconeogenesis, (2) Increasing insulin sensitivity in peripheral tissues like skeletal muscle, and (3) Delaying intestinal glucose absorption.
• AMPK Activation: It activates the enzyme AMP-activated protein kinase (AMPK), which plays a crucial role in cellular energy homeostasis and lipid metabolism.
• Cardiovascular & Weight Benefits: Unlike sulfonylureas, Metformin is weight-neutral or promotes modest weight loss and has demonstrated significant long-term cardiovascular protective effects in diabetic populations.

Technical & Manufacturing Specifications

Formulated for high drug-loading efficiency and optimized release kinetics.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from ISO 9001:2015 certified units.

• SR/ER Matrix Technology: Our Sustained-Release tablets utilize a dual-polymer matrix system that ensures a slow, steady release of the drug, significantly reducing gastrointestinal side effects and improving patient adherence with once-daily dosing.
• High-Dosage Compression: Metformin tablets often contain high amounts of API (up to 1000 mg). Our process uses advanced wet granulation to ensure tablet hardness and integrity while maintaining rapid disintegration for IR variants.
• Impurity Control: We conduct rigorous screening for NDMA (N-Nitrosodimethylamine), ensuring our products meet the latest global safety standards and regulatory thresholds.

Therapeutic Indications & Clinical Symptoms

• Type 2 Diabetes Mellitus: First-line treatment for glycemic control, especially in overweight patients when diet and exercise alone fail.
• Polycystic Ovary Syndrome (PCOS): Off-label use for managing insulin resistance and improving ovulatory function in women with PCOS.
• Prediabetes: Prevention of Type 2 Diabetes in high-risk individuals with impaired glucose tolerance.

Dosage & Administration

• Titration: To minimize GI upset, therapy is typically started at 500 mg once or twice daily, increasing gradually to a maximum of 2000–2550 mg per day.
• Administration: Must be taken with or after meals to reduce gastrointestinal side effects.
• Safety Note: Contraindicated in patients with severe renal impairment ($eGFR < 30$ mL/min/1.73m²) due to the risk of lactic acidosis.

Global Export & Contract Manufacturing Services

Healthy Inc is a verified Pharmaceutical Exporter in Mumbai, catering to Diabetes Centers and Ministry of Health Tenders. We offer Third Party Manufacturing for Metformin (IR & SR) with full CTD Dossier and COPP support. Our logistics network facilitates large-scale transit to Vietnam, Nigeria, UAE, and the Philippines, providing WHO-GMP quality at competitive B2B prices.

Commercial Inquiries

WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in