Description
Zidovudine Tablets (300 mg)
Healthy Inc is a specialized global supplier of essential Antiretroviral (ARV) medicines. We provide Zidovudine 300 mg Tablets (also known as AZT), manufactured in WHO–GMP certified facilities dedicated to high-containment infectious disease therapeutics. As a foundational Nucleoside Reverse Transcriptase Inhibitor (NRTI), this product is a critical export for HIV/AIDS clinics, National AIDS Control Organizations (NACO), and Maternal-to-Child Transmission (PMTCT) programs in Africa, Southeast Asia, and LATAM.
Product Overview
Zidovudine is a pyrimidine analog that serves as a cornerstone of Highly Active Antiretroviral Therapy (HAART). It is specifically engineered to halt the replication of the Human Immunodeficiency Virus (HIV-1 and HIV-2).
The “Chain Termination” Specialist:
- Mechanism of Action: Zidovudine is an intracellular prodrug. Once phosphorylated into its active form, Zidovudine Triphosphate, it competes with the natural substrate (deoxythymidine triphosphate) for incorporation into the viral DNA by the enzyme Reverse Transcriptase.
- DNA Chain Termination: Once incorporated, the lack of a 3′-hydroxyl group on the zidovudine molecule prevents the formation of 5′-3′ phosphodiester bonds. This causes immediate premature DNA chain termination, effectively stopping the synthesis of the viral DNA provirus.
- Blood-Brain Barrier Penetration: Unlike many other ARVs, Zidovudine exhibits excellent penetration into the Central Nervous System (CNS), making it vital for treating HIV-associated dementia and neurological complications.
Technical & Manufacturing Specifications
Formulated for consistent therapeutic levels and clinical safety.
| Technical Metric | Specification Standard |
|---|---|
| Active Ingredient | Zidovudine BP / USP / IP |
| Dosage Form | Film-Coated Tablet (300 mg) |
| Assay (Purity) | 97.0% – 102.0% |
| HS Code | 3004.90.99 (Antivirals / ARV Medicaments) |
| Packaging | HDPE Bottles with Desiccant or Alu-Alu Blisters |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from high-containment WHO-GMP units.
- Cytotoxic Handling Protocols: Our facility employs closed-system manufacturing for Zidovudine to prevent cross-contamination and ensure the highest purity for immunocompromised patients.
- Advanced Coating: Tablets are finished with a specialized film coating to protect the active ingredient from light-induced degradation and to ensure easier swallowability for patients on long-term daily regimens.
- Dissolution Integrity: Every batch is tested using HPLC-based dissolution monitoring to ensure 100% bioequivalence with the innovator brand (Retrovir).
Therapeutic Indications & Clinical Symptoms
- HIV-1 Infection: Used in combination with other ARVs (such as Lamivudine) for the treatment of HIV/AIDS.
- PMTCT (Prevention of Maternal-to-Child Transmission): Indicated for HIV-positive pregnant women to prevent the transmission of the virus to the fetus.
- Post-Exposure Prophylaxis (PEP): A critical component of emergency regimens after occupational exposure to HIV-contaminated blood.
Dosage & Administration
- Administration: Typically 300 mg twice daily. Can be taken with or without food.
- Warning: Requires regular monitoring of Hematological profiles (CBC) due to the risk of bone marrow suppression, specifically anemia and neutropenia.
Global Export & Contract Manufacturing Services
Healthy Inc is a verified Pharmaceutical Exporter in Mumbai, specializing in bulk supply for National AIDS Programs and NGO Tenders (e.g., Global Fund, USAID). We offer Third Party Manufacturing for Zidovudine with full CTD Dossier support for registration. Our logistics team handles international transit for ARVs to South Africa, Kenya, Vietnam, and Brazil, ensuring the highest standards of B2B pharmaceutical trade.
Commercial Inquiries
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
