Artesunate & Mefloquine Hydrochloride Tablets (ACT Combo)
Healthy Inc is a premier global provider of advanced Artemisinin-based Combination Therapies (ACTs). We provide premium Artesunate + Mefloquine Tablets, manufactured in WHO–GMP certified sterile and solid dosage facilities. This combination is a “rescue” therapy for multidrug-resistant (MDR) malaria and is a vital export for Ministry of Health tenders, NGO relief programs, and specialized clinics in Southeast Asia, Africa, and South America.
Product Overview
Artesunate + Mefloquine (AS+MQ) is a highly potent therapeutic regimen designed to combat the most resilient strains of Plasmodium falciparum. By combining a rapid-acting artemisinin derivative with a long-acting quinoline methanol, this therapy ensures both immediate parasite reduction and long-term clearance.
The “Multi-Drug Resistance” Specialist:
- Synergistic Dual-Action: Artesunate initiates rapid clearance of the parasite biomass (PCT < 24h) by generating lethal free radicals. Mefloquine, with its significantly longer half-life (approx. 2 weeks), eliminates any residual parasites, effectively preventing recrudescence and slowing the development of further resistance.
- Stage-Specific Efficacy: This combination targets parasites at multiple stages of the erythrocytic cycle, including the ring, trophozoite, and gametocyte stages, thereby also reducing the transmission potential of the disease.
- WHO Compliance: Our formulations strictly adhere to WHO guidelines for the treatment of uncomplicated malaria, providing a standardized 3-day treatment course that optimizes patient compliance.
Technical & Manufacturing Specifications
Available as Fixed-Dose Combination (FDC) or Co-blistered packs for logistical flexibility.
| Technical Metric | Specification Standard |
|---|---|
| Active Ingredient | Artesunate (AS) + Mefloquine HCl (MQ) |
| Available Strengths | (25/55 mg), (100/220 mg), (200/250 mg) |
| Dosage Form | Film-Coated Tablets (Uncoated also available) |
| HS Code | 3004.90.59 (Mefloquine Salts) / 3004.20.19 |
| Stability | Validated for Zone IVb (Hot/Humid) climates |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from ISO 9001:2015 certified units.
- Advanced Photoprotection: Artesunate is extremely light-sensitive. We utilize specialized opaque film coatings and Alu-Alu (Cold-form) blister packaging to ensure the endoperoxide bridge remains stable for a 36-month shelf life.
- Bioavailability Optimization: Mefloquine absorption is highly dependent on formulation. Our tablets are engineered to provide consistent dissolution profiles, ensuring therapeutic plasma levels are reached quickly even in patients with high parasitic loads.
- Rigorous Impurity Profiling: We conduct high-performance liquid chromatography (HPLC) on every batch to ensure the absence of Artesunate degradation products (such as DHA-alpha), maintaining the highest safety standards for pediatric use.
Therapeutic Indications & Clinical Symptoms
- Uncomplicated P. falciparum Malaria: Primary treatment in areas where parasites are resistant to chloroquine, sulfadoxine-pyrimethamine, or amodiaquine.
- MDR Malaria Hotspots: Particularly utilized in the Greater Mekong Subregion and specific African territories with high-level mefloquine sensitivity.
- Mixed Infections: Effective against malaria involving multiple species including P. vivax (blood-stage).
Dosage & Safety Guidelines
- Standard Course: 3-day treatment. Adult dose typically 2 tablets (100/200 mg) once daily for 3 days.
- Administration: Take with a full glass of water. Taking with food or milk may reduce GI irritation and improve Mefloquine absorption.
- Safety Note: Contraindicated in patients with a history of psychiatric disorders (depression, generalized anxiety, schizophrenia) or seizures, due to the neuro-psychiatric profile of Mefloquine. Do not use within 2 months of a previous mefloquine dose.
Global Export & Contract Manufacturing Services
Healthy Inc is a verified Antimalarial Exporter in Mumbai, catering to Global Health Tenders and Private Distribution Networks. We offer Third Party Manufacturing for Artesunate + Mefloquine with full Dossier, COPP, and Stability support. Our logistics network ensures seamless delivery to Cambodia, Myanmar, Nigeria, and Brazil, providing WHO-GMP quality at competitive B2B prices.
Commercial Inquiries
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in