Citicoline Controlled Release Tablets
Healthy Inc is a specialized global supplier and exporter of advanced neuro-regenerative agents. We provide high-stability Citicoline Sodium Controlled Release (CR) Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Brain Repair” specialist is a top export to neurology centers, stroke rehabilitation units, and geriatric care facilities in Africa, LATAM, and Southeast Asia, serving as a critical neuroprotective agent for the recovery of Ischemic Stroke and the management of Vascular Dementia.
Product Overview
This formulation contains Citicoline Sodium (CDP-Choline), an endogenous nucleotide intermediate in the synthesis of structural membrane phospholipids.
The “Neuro-Restorative” Specialist:
- Mechanism: Upon ingestion, Citicoline releases two essential components: Cytidine and Choline. These cross the Blood-Brain Barrier (BBB) and are reassembled into Phosphatidylcholine, a primary component of neuronal cell membranes. This repairs damaged neurons and restores membrane integrity.
- Controlled Release Advantage: Standard Citicoline is rapidly metabolized. Our Controlled Release (CR) technology utilizes a hydrophilic matrix to release the drug steadily over 12–24 hours. This ensures constant plasma levels, maximizes the “therapeutic window” for brain repair, and improves compliance in elderly or stroke patients who struggle with multiple daily doses.
- Neurotransmitter Support: It also enhances the production of Acetylcholine, Dopamine, and Norepinephrine, improving attention, focus, and memory recall.
Product Composition & Strength
We supply this product as Controlled Release (CR) Tablets (Film Coated). The matrix formulation is critical to extend the biological half-life.
| Active Ingredient | Strength | Release Profile | Primary Indication |
|---|---|---|---|
| Citicoline Sodium USP/IP | 500 mg | Controlled Release | Mild Cognitive Impairment / Maintenance |
| Citicoline Sodium USP/IP | 1000 mg | Controlled Release | Acute Stroke Recovery / Severe Dementia |
| Excipients | Q.S. | HPMC (Release Retardant) / Magnesium Stearate | Matrix System |
*Pack Sizes: Blister packs of 10s (Box of 10×10), Alu-Alu Strips of 10s, or Bulk HDPE Jars of 500s.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Tablet (Controlled Release) |
| Packaging | Alu-Alu Blister (Highly Hygroscopic) |
| Storage | Store below 25°C. Protect strictly from moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Hygroscopicity Management: Citicoline Sodium is extremely hygroscopic (absorbs moisture from air instantly). We manufacture in low-humidity suites (<30% RH) and use Cold Form Alu-Alu packaging to prevent the tablet from degrading into a liquid state inside the blister.
- Dissolution Testing: We perform rigorous time-point dissolution (e.g., 2h, 6h, 12h) to verify the controlled release profile matches the clinical requirement for sustained neuroprotection.
Therapeutic Indications (Human Use)
Indicated for the treatment of neurological disorders:
- Acute Ischemic Stroke: To accelerate recovery of consciousness and motor deficit (best if started within 24 hours).
- Vascular Dementia / Alzheimer’s: Slows the progression of memory loss and cognitive decline.
- Head Trauma (TBI): Treatment of neurological sequelae associated with traumatic brain injury.
- Glaucoma (Off-Label): Used as a neuroprotectant to prevent optic nerve damage.
Dosage & Administration
Recommended Dosage (Strictly as per Neurologist):
- Route: Oral.
- Acute Stroke / TBI: 1000 mg to 2000 mg daily for 6 weeks.
- Chronic Cognitive Decline: 500 mg to 1000 mg once daily.
- Administration Rules (CRITICAL):
- Swallow Whole: Do not chew, crush, or break the tablet. Breaking the matrix destroys the controlled release mechanism, leading to “dose dumping.”
- Timing: Can be taken with or without food. Taking in the morning is preferred to avoid insomnia due to dopaminergic stimulation.
Safety Warnings:
- Hypertonia: Contraindicated in patients with hypertonia (excessive muscle tone) of the parasympathetic nervous system.
- Insomnia: Can cause sleeplessness or excitement due to increased brain energy metabolism. If this occurs, take the dose earlier in the day.
- Drug Interactions: Citicoline increases the effects of L-Dopa (Parkinson’s medication). Dose adjustment of L-Dopa may be needed.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in