Loperamide Hydrochloride Tablets (2 mg)

Healthy Inc is a premier global supplier of high-stability gastrointestinal therapies. We provide premium Loperamide Hydrochloride Tablets, manufactured in WHO–GMP certified specialized solid dosage units. As the gold standard for the symptomatic relief of acute and chronic diarrhea, this product is a vital export for pharmacy chains, emergency relief organizations, and Ministry of Health (MOH) tenders in Southeast Asia, Africa, and Latin America.

Product Overview

Loperamide is a synthetic phenylpiperidine derivative and a long-acting antidiarrheal agent. It is specifically engineered to slow intestinal transit by acting on the circular and longitudinal muscles of the intestinal wall, providing rapid relief from diarrhea without significant central nervous system effects at therapeutic doses.

The “Intestinal Stability” Specialist:

• Mechanism of Action: Loperamide binds to the mu-opioid receptors in the myenteric plexus of the intestinal wall. This action inhibits the release of acetylcholine and prostaglandins, thereby reducing peristaltic activity and increasing the intestinal transit time.
• Fluid Absorption: By slowing the passage of gut contents, it increases the absorption of water and electrolytes. It also increases the tone of the anal sphincter, reducing fecal urgency and incontinence.
• Peripheral Selectivity: Loperamide is a substrate for P-glycoprotein, which effectively pumps the drug out of the blood-brain barrier. This ensures that its effects remain localized to the gastrointestinal tract, minimizing the risk of opioid-like CNS effects.

Technical & Manufacturing Specifications

Formulated for rapid onset and chemical integrity in diverse storage conditions.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from ISO 9001:2015 certified units.

• Dosage Precision: Loperamide is highly potent at low dosages. Our manufacturing utilizing validated geometric mixing ensures 100% content uniformity across every 2 mg tablet, preventing sub-therapeutic or excessive dosing.
• Dissolution Velocity: Engineered for rapid disintegration ($< 10$ minutes) to ensure fast interaction with intestinal receptors during acute diarrhea episodes.
• Stability Validation: Validated for Zone IVb (40°C / 75% RH). Our formulation maintains molecular stability against oxidation, ensuring a reliable 36-month shelf life for global export markets.

Therapeutic Indications & Clinical Symptoms

• Acute Diarrhea: Symptomatic relief of sudden, short-term diarrhea in adults and children over 6 years.
• Chronic Diarrhea: Management of persistent diarrhea associated with Inflammatory Bowel Disease (IBD) or Irritable Bowel Syndrome (IBS).
• Ileostomy Output Reduction: Used to reduce the volume of discharge in patients with ileostomies.
• Traveler’s Diarrhea: Essential component of travel kits for managing intestinal upsets during transit.

Dosage & Administration

• Acute Diarrhea: 4 mg (two tablets) initially, followed by 2 mg (one tablet) after each unformed stool. Max 16 mg/day.
• Hydration Note: Loperamide treats the symptoms, not the cause. It must be used in conjunction with Oral Rehydration Salts (ORS) to prevent dehydration.
• Contraindications: Not for use in cases of bacterial enterocolitis (e.g., Salmonella, Shigella) or pseudomembranous colitis associated with broad-spectrum antibiotics.

Global Export & Contract Manufacturing Services

Healthy Inc is a verified Pharmaceutical Exporter in Mumbai, catering to Retail Pharmacy Chains and Humanitarian Aid Tenders. We offer Third Party Manufacturing for Loperamide with full CTD Dossier and COPP support. Our logistics network facilitates secure transit to Vietnam, Nigeria, Kenya, and Brazil, providing WHO-GMP quality at competitive B2B prices.

Commercial Inquiries

WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in