Methyldopa Tablets (250 mg / 500 mg)

Healthy Inc is a premier global supplier of specialized cardiovascular and obstetric medicine. We provide premium Methyldopa Tablets, manufactured in WHO–GMP certified dedicated facilities. As the gold standard for managing hypertension during pregnancy, this product is a vital export for maternity hospitals, prenatal clinics, and Ministry of Health (MOH) tenders in Southeast Asia, Africa, and Latin America.

Product Overview

Methyldopa is a centrally acting antihypertensive agent. Unlike peripheral vasodilators, it is a prodrug that is metabolized in the brain to an active metabolite, which then modulates the sympathetic nervous system to reduce blood pressure effectively and safely.

The “Gestational Safety” Specialist:

• Mechanism of Action: Methyldopa is converted to alpha-methylnorepinephrine in the central nervous system. This metabolite stimulates central alpha-2 adrenergic receptors, which inhibits the sympathetic outflow from the brainstem to the heart and blood vessels, resulting in a decrease in peripheral vascular resistance.
• First-Line in Pregnancy: Methyldopa is globally recognized as the treatment of choice for chronic hypertension in pregnancy and gestational hypertension. It has a long-standing safety record, showing no evidence of teratogenicity or adverse effects on fetal hemodynamics.
• Renal Preservation: Methyldopa maintains renal blood flow and glomerular filtration rate, making it a suitable option for hypertensive patients with compromised renal function.

Technical & Manufacturing Specifications

Formulated for high molecular stability and consistent therapeutic index.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from ISO 9001:2015 certified units.

• Crystalline Integrity: We utilize high-purity Methyldopa API, ensuring that the sesquihydrate crystalline form is maintained throughout the compression process to guarantee predictable dissolution and bioavailability.
• Impurity Profiling: Our quality control labs conduct rigorous testing for 3-O-methylmethyldopa and other related substances using validated HPLC methods to ensure maximum safety for maternal and fetal health.
• Stability Validation: Our tablets are validated for Climatic Zone IVb, ensuring the product remains chemically potent even in high-temperature, high-humidity tropical environments common in export markets.

Therapeutic Indications & Clinical Symptoms

• Gestational Hypertension: Management of high blood pressure during pregnancy.
• Pre-eclampsia: Adjunctive therapy in the management of pre-eclamptic patients.
• Essential Hypertension: Treatment of mild to moderate high blood pressure in patients who cannot tolerate other classes of antihypertensives.

Dosage & Administration

• Initial Dose: Typically 250 mg two to three times daily.
• Maintenance: Dosage may be adjusted at intervals of not less than two days until an adequate response is achieved. Max dose is 3g/day.
• Clinical Note: May cause sedation or drowsiness during the initial stages of treatment or when the dose is increased. A positive Coombs test may occur in some patients on long-term therapy.

Global Export & Contract Manufacturing Services

Healthy Inc is a verified Pharmaceutical Exporter in Mumbai, catering to Maternity Hospitals and Government Health Tenders. We offer Third Party Manufacturing for Methyldopa with full CTD Dossier and COPP support. Our logistics network ensures secure transit to Vietnam, Nigeria, Kenya, and Brazil, providing WHO-GMP quality at competitive B2B prices.

Commercial Inquiries

WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in