Nicoumalone Tablets (1 mg / 2 mg / 3 mg / 4 mg)

Healthy Inc is a specialized global supplier of high-stability anticoagulant therapies. We provide premium Nicoumalone Tablets (also known as Acenocoumarol), manufactured in WHO–GMP certified specialized solid dosage facilities. As a critical agent in thromboembolic management, this product is a primary export for cardiology centers, hematology wards, and vascular surgery units across Southeast Asia, Africa, and the CIS region.

Product Overview

Nicoumalone is a potent coumarin derivative and a Vitamin K antagonist. It is specifically engineered to provide a faster onset and a shorter duration of action compared to Warfarin, allowing for more rapid dose adjustments and enhanced safety during surgical transitions.

The “Precision Anticoagulant” Specialist:

• Mechanism of Action: Nicoumalone inhibits the enzyme Vitamin K Epoxide Reductase (VKORC1). This prevents the recycling of Vitamin K, thereby inhibiting the gamma-carboxylation of Vitamin K-dependent clotting factors (Factors II, VII, IX, and X). This effectively thins the blood and prevents the formation of pathological clots.
• Pharmacokinetic Advantage: With a half-life of approximately 8–11 hours, Nicoumalone offers finer control over anticoagulation levels. If the INR (International Normalized Ratio) exceeds the target range, the effect dissipates more quickly than other VKAs upon discontinuation.
• Predictable Absorption: It exhibits high oral bioavailability and rapid absorption, ensuring that therapeutic levels are reached consistently within the early phase of treatment.

Technical & Manufacturing Specifications

Formulated for absolute dosage precision and chemical stability.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from ISO 9001:2015 certified units.

• High-Precision Scored Design: Because anticoagulant dosing is highly individualized, our tablets are precisely scored to allow for accurate half-dosing or quarter-dosing, which is vital for maintaining a stable INR.
• Content Uniformity: Due to the low drug load (e.g., 1 mg), we utilize validated geometric dilution and high-precision blending to ensure that every microgram of the active pharmaceutical ingredient (API) is distributed evenly.
• Stability Monitoring: Nicoumalone is validated for Climatic Zone IVb, ensuring the product remains chemically stable for 36 months even in high-humidity tropical export markets.

Therapeutic Indications & Clinical Symptoms

• Deep Vein Thrombosis (DVT): Treatment and prophylaxis of venous thrombosis and pulmonary embolism.
• Atrial Fibrillation (AF): Prevention of thromboembolic complications (stroke) in patients with chronic AF.
• Heart Valve Replacement: Long-term anticoagulation for patients with prosthetic heart valves.
• Post-Myocardial Infarction: Reduction of the risk of systemic embolism following acute MI.

Dosage & Administration

• INR-Based Dosing: Dosing is entirely dependent on the patient’s INR (International Normalized Ratio). The target range is typically 2.0 to 3.0 for most indications.
• Administration: Should be taken as a single daily dose at the same time each day, ideally in the evening.
• Safety Note: Contraindicated in pregnancy and patients with high bleeding risk. Patients must avoid significant fluctuations in dietary Vitamin K intake (e.g., green leafy vegetables).

Global Export & Contract Manufacturing Services

Healthy Inc is a verified Pharmaceutical Exporter in Mumbai, catering to Specialty Cardiac Centers and Ministry of Health Tenders. We offer Third Party Manufacturing for Nicoumalone with full CTD Dossier support. Our logistics network ensures secure transit to Vietnam, Nigeria, Uzbekistan, and the Philippines, providing WHO-GMP quality at competitive B2B prices.

Commercial Inquiries

WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in