Description
Amlodipine Besylate & Losartan Potassium Tablets
Healthy Inc is a specialized global supplier and exporter of advanced cardiovascular combinations. We provide premium Amlodipine Besylate & Losartan Potassium Tablets, sourced from WHO–GMP certified solid dosage facilities. This synergistic “Dual-Mechanism” antihypertensive therapy is a primary export to cardiology clinics, internal medicine departments, and government health ministries in Africa, LATAM, and Southeast Asia, specifically designed for patients whose blood pressure is not adequately controlled by monotherapy.
Product Overview
This formulation combines a Calcium Channel Blocker (CCB) with an Angiotensin II Receptor Blocker (ARB) to provide comprehensive vascular protection and systemic blood pressure reduction.
The “Vascular Protection” Specialist:
- Amlodipine Besylate (The Vasodilator): A long-acting dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. This results in direct peripheral arterial vasodilation, reducing total peripheral resistance and blood pressure.
- Losartan Potassium (The RAAS Inhibitor): A selective AT1 receptor antagonist. It blocks the vasoconstrictor and aldosterone-secreting effects of Angiotensin II. By preventing Angiotensin II from binding to its receptor, it promotes vasodilation and reduces water/sodium retention.
- Synergistic Advantage: The combination targets two distinct physiological pathways. Clinical data suggests that the addition of Losartan can help mitigate the peripheral edema (ankle swelling) sometimes caused by Amlodipine monotherapy, improving patient tolerability.
Product Composition & Strength
We supply this product as Film Coated Tablets. The formulation is optimized for 24-hour efficacy, allowing for convenient once-daily dosing.
| Active Ingredient | Strength (Standard) | Therapeutic Role | |
|---|---|---|---|
| Amlodipine Besylate BP/USP | 5 mg | Calcium Channel Blocker (CCB) | |
| Losartan Potassium BP/USP | 50 mg | Angiotensin Receptor Blocker (ARB) | |
| Excipients | Q.S. | Microcrystalline Cellulose / Starch | Stabilizing Core Matrix |
*Other common strengths like 5mg/100mg or 10mg/50mg are available upon request for contract manufacturing.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Cardiovascular Medicaments) |
| Dosage Form | Tablet (Film Coated) |
| Packaging | Alu-Alu Blister (Recommended for moisture sensitivity) |
| Storage | Store below 30°C. Protect from light and moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Stability Engineering: Losartan Potassium is highly hygroscopic (absorbs moisture). Our manufacturing process utilizes Low-Humidity Environment control and specialized Alu-Alu cold-form packaging to prevent degradation and ensure a stable 24-month shelf life in tropical export regions.
- Dissolution Profile: We ensure that both active ingredients release at an optimized rate to achieve steady-state plasma concentrations, maintaining blood pressure control throughout the 24-hour dosing interval.
Therapeutic Indications (Human Use)
Indicated for the management of hypertension:
- Essential Hypertension: Treatment of high blood pressure in patients not adequately controlled on single-agent therapy.
- Cardiovascular Risk Reduction: In hypertensive patients with left ventricular hypertrophy, reducing the risk of stroke.
- Renoprotection: Specifically beneficial for hypertensive patients with Type 2 Diabetes and nephropathy.
Dosage & Administration
Recommended Dosage (Strictly as per Cardiologist):
- Route: Oral.
- Standard Dose: One tablet (5mg/50mg) once daily.
- Administration: Can be taken with or without food. Consistency in timing (e.g., every morning) is recommended for optimal blood pressure management.
Safety Warnings:
- Pregnancy Warning: BLACK BOX WARNING: ARBs like Losartan can cause injury or death to the developing fetus. Discontinue immediately if pregnancy is detected.
- Hyperkalemia: Risk of increased potassium levels; monitor patients, especially those with renal impairment or those taking potassium supplements.
- Hypotension: Symptomatic hypotension may occur, particularly in volume-depleted patients.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
