Description
Amlodipine & Lisinopril Tablets
Healthy Inc is a specialized global supplier and exporter of advanced Fixed-Dose Combination (FDC) antihypertensives. We provide high-stability Amlodipine (as Besylate) & Lisinopril (as Dihydrate) Tablets, sourced from WHO–GMP certified solid dosage facilities. This synergistic “CCB + ACE Inhibitor” therapy is a critical export for cardiology centers, hypertension clinics, and National Health Tenders in Africa, LATAM, and Southeast Asia, offering superior blood pressure control compared to monotherapy.
Product Overview
This formulation combines a Calcium Channel Blocker (CCB) with an Angiotensin-Converting Enzyme (ACE) Inhibitor to provide a comprehensive approach to vascular relaxation and fluid regulation.
The “Vascular Synergy” Specialist:
- Amlodipine (CCB): A long-acting dihydropyridine that inhibits the influx of calcium ions into vascular smooth muscle. This leads to direct peripheral arterial vasodilation, reducing systemic vascular resistance and lowering blood pressure.
- Lisinopril Dihydrate (ACE Inhibitor): Inhibits the enzyme responsible for converting Angiotensin I to Angiotensin II (a potent vasoconstrictor). By lowering Angiotensin II levels, it promotes vasodilation and decreases aldosterone secretion, which reduces sodium and water retention.
- The “Neutralizing” Effect: One significant clinical advantage of this combination is that Lisinopril can help mitigate the peripheral edema (ankle swelling) often caused by Amlodipine-induced vasodilation, improving patient compliance and long-term outcomes.
Product Composition & Strength
We supply this product as Uncoated or Film Coated Tablets. The use of Lisinopril in its Dihydrate form ensures superior stability and predictable dissolution profiles.
| Active Ingredient | Strength (Standard) | Therapeutic Role | |
|---|---|---|---|
| Amlodipine (as Besylate) BP/USP | 5 mg / 10 mg | Calcium Channel Blocker | |
| Lisinopril (as Dihydrate) BP/USP | 5 mg / 10 mg / 20 mg | ACE Inhibitor | |
| Excipients | Q.S. | Calcium Phosphate / Mannitol | Stabilizing Agents |
*Common strengths include 5/5mg, 5/10mg, and 10/20mg. Pack Sizes: Alu-Alu Blister packs of 10s, 28s, or 30s.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Cardiovascular Medicaments) |
| CAS Numbers | Amlodipine (111470-99-6); Lisinopril (83915-83-7) |
| Packaging | Alu-Alu Blister (Protects Lisinopril from moisture) |
| Storage | Store below 25°C. Protect from moisture and light. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Stability Engineering: Lisinopril is highly sensitive to moisture and can undergo cyclization to form diketopiperazine. Our manufacturing process utilizes Dry Granulation (Slugging/Roll Compaction) to ensure a moisture-free environment, maintaining 100% potency over a 36-month shelf life.
- Precision Blending: We ensure strict content uniformity, critical for low-dose 5mg combinations, providing consistent blood pressure reduction in every dose.
Therapeutic Indications (Human Use)
Indicated for the treatment of hypertension:
- Essential Hypertension: For patients whose blood pressure is not adequately controlled with Amlodipine or Lisinopril monotherapy.
- Substitution Therapy: For patients already receiving both drugs as separate tablets at the same dose levels.
Dosage & Administration
Recommended Dosage (Strictly as per Physician):
- Route: Oral.
- Standard Dose: 1 tablet daily.
- Administration: Should be taken at the same time each day, with or without food. Consistent timing is vital for maintaining 24-hour vascular control.
Safety Warnings:
- Pregnancy: BLACK BOX WARNING: ACE inhibitors like Lisinopril can cause injury or death to the developing fetus. Discontinue immediately if pregnancy is detected.
- Angioedema: Use with caution in patients with a history of swelling of the face/lips/tongue.
- Renal Function: Monitor serum creatinine and potassium levels regularly, especially in patients with pre-existing kidney disease.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
