Description
Carbamazepine Tablets
Healthy Inc is a specialized global supplier and exporter of foundational neurological and psychiatric therapeutics. We provide high-purity Carbamazepine Tablets, sourced from WHO–GMP certified solid dosage facilities. This “First-Generation” Anticonvulsant is a top export to neurology departments, psychiatric hospitals, and government health formularies in Africa, LATAM, and Southeast Asia, serving as the gold standard for treating focal epilepsy and the specific drug of choice for Trigeminal Neuralgia.
[Image of Carbamazepine mechanism of action blocking voltage-gated sodium channels]
Product Overview
This formulation contains Carbamazepine, an iminostilbene derivative related to tricyclic antidepressants.
The “Voltage Stabilizer” Specialist:
- Mechanism: Carbamazepine works by stabilizing hyper-excited nerve membranes. It blocks voltage-gated sodium channels, preventing the repetitive firing of neuronal action potentials. This stops the spread of seizure activity in the brain.
- Pain Control: In Trigeminal Neuralgia (severe facial pain), it dampens the synaptic transmission in the trigeminal nucleus, providing specific relief where standard painkillers fail.
- Mood Stabilization: It is also used in Bipolar Disorder to prevent manic episodes, acting on secondary messenger systems (inositol depletion).
- Auto-Induction (Unique Feature): Carbamazepine stimulates the liver enzymes (CYP3A4) that break it down. This means over the first few weeks of treatment, the body becomes too good at eliminating it, often requiring a dose increase to maintain the same effect.
Product Composition & Strength
We supply this product as Uncoated or Film Coated Tablets (White, scored). We also offer Controlled Release (CR) variants upon request.
| Active Ingredient | Strength (Standard) | Primary Role |
|---|---|---|
| Carbamazepine USP/BP | 100 mg | Pediatric / Initiation Dose |
| Carbamazepine USP/BP | 200 mg | Standard Adult Dose |
| Carbamazepine USP/BP | 400 mg | High Dose / CR Formulation |
| Excipients | Q.S. | Microcrystalline Cellulose / Sodium Starch Glycolate |
*Pack Sizes: Blister packs of 10s (Box of 10×10), 100s, or Bulk HDPE Jars of 1000s (Hospital Packs).
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| CAS Number | 298-46-4 |
| Dosage Form | Tablet (Immediate Release / CR) |
| Packaging | Alu-Alu Blister or PVC-PVDC (Moisture Sensitive) |
| Storage | Store below 25°C. Protect from Humidity. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Polymorph Control (CRITICAL): Carbamazepine exists in at least four polymorphic forms. Form III is the therapeutic form. If stored in high humidity or manufactured incorrectly, it can convert to the Dihydrate form, which has one-third the dissolution rate of the original, leading to immediate treatment failure. Our manufacturing and packaging are strictly controlled to prevent this hydration.
- Dissolution: Validated dissolution profiles ensure consistent bioavailability, minimizing the risk of breakthrough seizures.
Therapeutic Indications (Human Use)
Indicated for the treatment of epilepsy and pain disorders:
- Epilepsy: Complex partial seizures, generalized tonic-clonic seizures (Grand Mal), and mixed seizure patterns. (Not effective for Absence Seizures).
- Trigeminal Neuralgia: First-line treatment for the paroxysmal pain of the trigeminal nerve (tic douloureux).
- Bipolar Disorder: Acute manic episodes and maintenance treatment in bipolar I disorder (especially for patients resistant to Lithium).
- Alcohol Withdrawal: Adjunct treatment to prevent withdrawal seizures.
Dosage & Administration
Recommended Dosage (Strictly as per Neurologist):
- Route: Oral.
- Epilepsy (Adults): Start with 100–200 mg once or twice daily. Increase slowly by 200 mg every week to minimize side effects.
- Maintenance: 800 mg to 1200 mg daily in divided doses.
- Trigeminal Neuralgia: Start with 100 mg twice daily. Increase until pain is free (usually 200–800 mg/day).
- Auto-Induction Note: Dosage often needs upward adjustment after the first month as the liver enzymes accelerate metabolism.
- Administration: Take with food to increase absorption and reduce stomach upset.
Safety Warnings:
- Serious Skin Reactions (SJS/TEN): Can cause fatal Stevens-Johnson Syndrome. Patients of Asian ancestry (Han Chinese, Thai, etc.) significantly benefit from genetic testing for the HLA-B*1502 allele before starting therapy.
- Bone Marrow Suppression: Can cause Aplastic Anemia or Agranulocytosis (severe drop in white blood cells). Regular blood counts are mandatory.
- Drug Interactions (Potent Inducer): Carbamazepine speeds up the metabolism of many other drugs (e.g., Oral Contraceptives, Warfarin, Doxycycline), rendering them ineffective.
- Hyponatremia: Can lower blood sodium levels (SIADH-like effect), causing confusion in the elderly.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
