Cilostazol Tablets

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Cilostazol Tablets 50 mg
Each Uncoated Tablet Contains:
Cilostazol 50 mg

Cilostazol Tablets 100 mg
Each Uncoated Tablet contains :
Cilostazol 100 mg

Usage: – improve the symptoms of a certain blood flow problem in the legs

Category: – Anti Hypertensive / Cardiac Drugs

Therapeutic category: – Anti Hypertensive

Description

Description

Cilostazol Tablets

Healthy Inc is a specialized global supplier and exporter of advanced peripheral vasodilators. We provide high-bioavailability Cilostazol Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Walking Distance Extender” is a top export to vascular surgery clinics, geriatric care centers, and government health formularies in Africa, LATAM, and Southeast Asia, recognized as the primary pharmacological intervention for Intermittent Claudication associated with Peripheral Arterial Disease (PAD).

Product Overview

This formulation contains Cilostazol, a selective Phosphodiesterase III (PDE3) inhibitor with dual therapeutic actions.

The “Mobility Restorer” Specialist:

Dual Mechanism:
- Antiplatelet: By inhibiting the PDE3 enzyme, it prevents the breakdown of cyclic AMP (cAMP) in platelets. Increased cAMP levels block platelet aggregation (clumping), preventing clots in narrowed arteries.
- Vasodilation: It also inhibits PDE3 in vascular smooth muscle cells, leading to relaxation and dilation of the arteries, particularly in the legs (femoral/popliteal beds).
Functional Improvement: Unlike other antiplatelets (like Aspirin) that only prevent events, Cilostazol actively improves symptoms. It is clinically proven to increase the distance a patient can walk without pain (Pain-Free Walking Distance) by improving blood flow to oxygen-starved muscles.
Lipid Effect: It has a favorable side effect profile on lipids, typically lowering Triglycerides (approx 15%) and raising HDL “Good” Cholesterol (approx 10%).

Product Composition & Strength

We supply this product as Uncoated Tablets (White, circular). Precise formulation is required to manage its solubility profile.

Active Ingredient	Strength (Standard)	Primary Role
Cilostazol USP/BP	50 mg	Initiation / Renal Adjustment
Cilostazol USP/BP	100 mg	Standard Maintenance Dose
Excipients	Q.S.	Microcrystalline Cellulose / CMC Calcium

*Pack Sizes: Blister packs of 10s (Box of 10×10), 14s, 30s, or Bulk HDPE Jars of 1000s.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

HS Code	3004.90.99 (Other Medicaments)
Dosage Form	Tablet (Oral)
Packaging	PVC-Alu Blister or Alu-Alu Blister
Storage	Store below 25°C. Protect from light and moisture.
Certificates	WHO-GMP, COPP, Free Sale Certificate

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

Nanomilling Technology: Cilostazol is a BCS Class II drug (low solubility, high permeability). Standard crystals absorb poorly. We utilize advanced Nano-milling or Micronization techniques to drastically increase the surface area of the API, ensuring consistent absorption and therapeutic blood levels.
Dissolution Profile: Our formulation is engineered to match the dissolution curve of the innovator (Pletal), ensuring bioequivalence.

Therapeutic Indications (Human Use)

Indicated for the symptomatic management of Peripheral Arterial Disease (PAD):

Intermittent Claudication: Reduction of symptoms (cramping pain in legs induced by exercise) enabling increased walking distance.
Stroke Prevention: Sometimes used for secondary prevention of cerebral infarction (stroke) in specific patient groups (popular in Asian protocols).

Dosage & Administration

Recommended Dosage (Strictly as per Vascular Surgeon):

Route: Oral.
Standard Dose: 100 mg taken twice daily (every 12 hours).
The “Empty Stomach” Rule (CRITICAL):
- Must be taken at least 30 minutes BEFORE or 2 hours AFTER breakfast and dinner.
- Taking Cilostazol with a high-fat meal dangerously increases absorption (up to 90% increase in Cmax), leading to severe headaches, palpitations, and hypotension.
Dose Reduction: Reduced to 50 mg twice daily if co-administered with CYP3A4 inhibitors (like Diltiazem, Ketoconazole, or Omeprazole).

Safety Warnings:

Heart Failure (BLACK BOX WARNING): Strictly Contraindicated in patients with Congestive Heart Failure of any severity. PDE3 inhibitors can decrease survival in these patients.
Headache & Palpitations: Very common side effects due to vasodilation. Patients should be counseled that this often improves with time.
Bleeding Risk: Use caution if combined with other antiplatelets (Aspirin/Clopidogrel) or anticoagulants.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.