Description
Colistimethate Sodium Injection (Colistin)
Healthy Inc is a specialized global supplier and exporter of critical care “last-resort” antibiotics. We provide high-purity Colistimethate Sodium Injection (Colistin), manufactured in our WHO–GMP certified facilities. This vital antibiotic is exported to hospitals and ICUs across Africa, LATAM, CIS, and Southeast Asia for the treatment of life-threatening infections caused by multi-drug resistant (MDR) Gram-negative bacteria.
Product Overview
Colistimethate Sodium is a cyclic polypeptide antibiotic belonging to the Polymyxin group. It acts by disrupting the bacterial cell membrane, leading to cell death.
It is the “Salvage Therapy” for:
- MDR Infections: Infections resistant to Carbapenems, Cephalosporins, and Aminoglycosides.
- Severe Pneumonia: Ventilator-associated pneumonia caused by Pseudomonas aeruginosa or Acinetobacter baumannii.
- Urosepsis: Complicated urinary tract infections caused by resistant pathogens.
Product Composition & Strength
We supply this product as a sterile lyophilized powder for reconstitution.
| Active Ingredient | Potency (International Units) | Approx. Mass |
|---|---|---|
| Colistimethate Sodium IP/USP | 1 Million IU (MIU) | ~ 80 mg |
| Colistimethate Sodium IP/USP | 2 Million IU (MIU) | ~ 160 mg |
| Colistimethate Sodium IP/USP | 4.5 Million IU (MIU) | ~ 360 mg |
*Supplied in glass vials with flip-off seals.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Hospital Tenders.
| HS Code | 3004.20.99 (Antibiotic Medicaments) |
| Dosage Form | Lyophilized Powder for Injection |
| Route of Administration | Intravenous (IV) Infusion / Intramuscular (IM) / Inhalation (Nebulization) |
| Packaging | Glass Vial (Single Pack or Tray Pack) |
| Storage | Store below 25°C. Protect from light. |
| Certificates | WHO-GMP, COPP, FSC, CTD Dossier |
Manufacturing Authority
Manufactured at our WHO-GMP & ISO 9001:2015 certified unit.
- Lyophilization: Advanced freeze-drying technology ensures high stability and rapid reconstitution.
- Purity: Stringent controls on specific optical rotation and related substances to minimize nephrotoxicity risks.
- Capacity: Dedicated lines for high-value critical care injectables.
Therapeutic Indications
Indicated for the treatment of severe acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly:
- Pseudomonas aeruginosa
- Acinetobacter baumannii
- Klebsiella pneumoniae (Carbapenem-resistant strains)
*Note: Not effective against Gram-positive bacteria or anaerobes.
Dosage & Administration
Strict Medical Supervision Required (ICU Setting):
- IV Administration: Usually 2.5 to 5 mg/kg per day, divided into 2 to 4 doses. (Dosage often calculated in Million Units).
- Renal Adjustment: Critical dosage adjustment required for patients with renal impairment to prevent kidney damage.
- Inhalation: Can be used via nebulizer for cystic fibrosis patients with lung infections.
Safety Warnings:
- Nephrotoxicity: High risk of kidney damage; monitor renal function (Creatinine/BUN) daily.
- Neurotoxicity: Monitor for dizziness, paresthesia, or neuromuscular blockade.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
