Description

Clozapine Tablets (25 mg / 50 mg / 100 mg)

Healthy Inc is a premier global provider of high-precision psychiatric interventions. We provide premium Clozapine Tablets, manufactured in WHO–GMP certified specialized neuro-psychiatric production units. As the gold-standard therapy for treatment-resistant schizophrenia, this product is a vital export for mental health institutes, psychiatric hospitals, and Ministry of Health (MOH) tenders in Southeast Asia, Africa, and the CIS region.

Product Overview

Clozapine is a “atypical” antipsychotic and the first of its class to demonstrate superior efficacy in patients who do not respond to standard neuroleptics. It is specifically engineered to manage both positive and negative symptoms of schizophrenia while maintaining a low profile for extrapyramidal side effects.

The “Treatment-Resistant” Specialist:

• Mechanism of Action: Unlike typical antipsychotics that primarily block D2 receptors, Clozapine has a unique, broad-spectrum neuro-receptor profile. It exhibits weak D2 dopamine receptor blockade but potent antagonism at 5-HT2A serotonin receptors, as well as activity at adrenergic, cholinergic, and histaminergic sites.
• Anti-Suicidal Efficacy: Clozapine is the only medication FDA-approved to reduce the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder.
• Reduced EPS: Due to its transient binding at D2 receptors and strong serotonergic activity, it significantly reduces the incidence of tardive dyskinesia and Parkinsonian symptoms compared to first-generation antipsychotics.

Technical & Manufacturing Specifications

Formulated for absolute bioavailability and consistent pharmacokinetic release.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from ISO 9001:2015 certified units.

• High-Containment Production: Clozapine is a highly potent psychotropic agent. Our manufacturing occurs in dedicated psychiatric drug suites with high-containment systems to prevent cross-contamination and ensure operator safety.
• Dissolution Uniformity: We utilize advanced granulation techniques to ensure that Clozapine, which is poorly soluble in water, achieves consistent dissolution rates to prevent sub-therapeutic plasma levels.
• Stability Validation: Validated for Zone IVb climates. Our tablets are engineered to withstand the extreme temperatures and humidity of global export markets, maintaining a 36-month shelf life.

Therapeutic Indications & Clinical Symptoms

• Treatment-Resistant Schizophrenia: For patients who fail to respond to at least two different antipsychotic medications.
• Suicidal Behavior: Reduction in the risk of recurrent suicidal behavior in schizophrenia patients.
• Psychosis in Parkinson’s Disease: Used at very low doses for managing hallucinations and delusions in PD patients.

Dosage & Administration

• Titration: Treatment must start with a very low dose (12.5 mg once or twice daily) and be increased slowly to minimize the risk of hypotension and seizures.
• Safety Monitoring: Mandatory ANC (Absolute Neutrophil Count) monitoring is required due to the risk of Agranulocytosis. Weekly blood tests are typical during the first six months of therapy.
• Safety Note: Monitor for myocarditis, cardiomyopathy, and seizures. Common side effects include hypersalivation (drooling), sedation, and weight gain.

Global Export & Contract Manufacturing Services

Healthy Inc is a verified Psychiatric Drug Exporter in Mumbai, catering to Mental Health Institutions and Ministry of Health Tenders. We offer Third Party Manufacturing for Clozapine with full CTD Dossier and international permit support. Our logistics network ensures secure transit to Vietnam, Nigeria, Uzbekistan, and the Philippines, providing WHO-GMP quality at competitive B2B prices.

Commercial Inquiries

WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in