Description
Diltiazem Hydrochloride Tablets
Healthy Inc is a specialized global supplier and exporter of “Rate-Limiting” Calcium Channel Blockers. We provide high-stability Diltiazem Hydrochloride Tablets (Immediate Release and Sustained Release), sourced from WHO–GMP certified solid dosage facilities. This “Cardiac Balancer” is a top export to cardiology clinics, hypertension management programs, and hospital formularies in Africa, LATAM, and Southeast Asia, serving as a versatile agent for controlling chest pain (Angina) while regulating heart rate.
[Image of Diltiazem mechanism blocking L-type calcium channels in cardiac muscle]
Product Overview
This formulation contains Diltiazem Hydrochloride, a non-dihydropyridine calcium channel blocker (Benzothiazepine class).
The “Dual-Action” Specialist:
- Mechanism: Diltiazem inhibits the influx of calcium ions through L-type voltage-gated calcium channels during depolarization. Unlike Amlodipine (which affects only blood vessels), Diltiazem affects both:
- Vascular Smooth Muscle: Relaxes coronary and peripheral arteries, reducing blood pressure and increasing oxygen supply to the heart.
- Cardiac Conduction System: Slows the electrical conduction through the AV node, reducing the heart rate.
- The “Cardiac Balancer”: Because it dilates arteries without causing reflex tachycardia (racing heart), it is ideal for patients with Angina who cannot tolerate beta-blockers.
- Renal Protection: It has beneficial effects on kidney function, reducing proteinuria in diabetic patients.
Product Composition & Strength
We supply this product as Film Coated Tablets (Immediate Release) or Sustained Release (SR) Tablets (Matrix Technology).
| Active Ingredient | Strength | Formulation | Role |
|---|---|---|---|
| Diltiazem HCl USP/BP | 30 mg | Immediate Release | Initial Titration / Angina |
| Diltiazem HCl USP/BP | 60 mg | Immediate Release | Standard Maintenance |
| Diltiazem HCl USP/BP | 90 mg / 120 mg | Sustained Release (SR) | Twice Daily Control |
| Excipients | Q.S. | HPMC (Release Matrix) / Lactose | Controlled Diffusion |
*Pack Sizes: Blister packs of 10s (Box of 10×10), 15s, 30s, or Bulk HDPE Jars of 1000s.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Tablet (Standard or SR) |
| Packaging | PVC-Alu Blister or Alu-Alu Blister |
| Storage | Store below 25°C. Protect from light and moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- SR Matrix Technology: Our Sustained Release tablets utilize a hydrophilic matrix system (Hydroxypropyl Methylcellulose). When ingested, the tablet forms a gel layer that regulates the diffusion of the drug, ensuring steady blood levels over 12 hours and preventing the “peak-and-trough” fluctuations that trigger angina attacks.
- Dissolution Testing: We perform rigorous multi-point dissolution testing (e.g., 1hr, 4hr, 8hr) on every SR batch to guarantee the release profile matches the innovator (Cardizem).
Therapeutic Indications (Human Use)
Indicated for the management of cardiovascular conditions:
- Chronic Stable Angina: Reduces the frequency of chest pain attacks.
- Vasospastic Angina (Prinzmetal’s): Relaxes coronary artery spasms.
- Hypertension: Lowers blood pressure (usually SR formulations).
- Atrial Fibrillation/Flutter: Controls rapid ventricular rate (Rate Control).
Dosage & Administration
Recommended Dosage (Strictly as per Cardiologist):
- Route: Oral.
- Immediate Release (30-60 mg):
- Start with 30 mg, 4 times daily (before meals and at bedtime).
- Titrate gradually to 180–360 mg/day in divided doses.
- Sustained Release (SR 90-120 mg):
- Usually taken twice daily (every 12 hours).
- Swallow whole; do not crush or chew.
- Timing: Consistency is key. Take at the same times each day.
Safety Warnings:
- Bradycardia & Heart Block: Diltiazem slows the heart. It is Contraindicated in patients with “Sick Sinus Syndrome” or 2nd/3rd-degree AV block (unless paced). Pulse must be monitored.
- Heart Failure: Use with caution in patients with reduced ejection fraction (weak heart pump), as it can further depress cardiac contractility.
- Drug Interactions (CYP3A4): Diltiazem inhibits the CYP3A4 enzyme. It can dangerously increase levels of Statins (Simvastatin/Atorvastatin), Carbamazepine, and Cyclosporine. Dose adjustments are mandatory.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
