Description
Disulfiram Tablets
Healthy Inc is a specialized global supplier and exporter of addiction management pharmacotherapies. We provide high-purity Disulfiram Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Aversion Therapy” agent is a top export to rehabilitation centers, psychiatric institutions, and government de-addiction programs in Africa, LATAM, and Southeast Asia, serving as a powerful pharmacological deterrent to support abstinence in chronic alcoholism.
Product Overview
This formulation contains Disulfiram, a thiuram derivative that alters the metabolism of alcohol.
The “Chemical Enforcer” Specialist:
- Mechanism (ALDH Inhibition): Normally, the liver breaks down alcohol into acetaldehyde, which is then rapidly converted into harmless acetate by the enzyme Acetaldehyde Dehydrogenase (ALDH). Disulfiram irreversibly inhibits ALDH.
- The Disulfiram-Ethanol Reaction (DER): If a patient drinks alcohol while taking this medication, acetaldehyde accumulates in the blood to toxic levels (5 to 10 times higher than normal). This triggers an immediate, intensely unpleasant physical reaction: severe flushing, throbbing headache, nausea, vomiting, chest pain, and anxiety.
- Psychological Deterrent: The fear of this reaction creates a psychological barrier (“Chemical Fence”) that helps the patient resist the urge to drink impulsively.
- Duration: Because it inhibits the enzyme irreversibly, the effect persists for up to 14 days after the last dose, preventing “weekend relapse.”
Product Composition & Strength
We supply this product as Uncoated Tablets (scored). The tablets are formulated to dissolve rapidly to ensure quick systemic coverage.
| Active Ingredient | Strength (Standard) | Role |
|---|---|---|
| Disulfiram USP/BP | 250 mg | Standard Maintenance |
| Disulfiram USP/BP | 500 mg | Induction Dose |
| Excipients | Q.S. | Microcrystalline Cellulose / Starch |
*Pack Sizes: Blister packs of 10s (Box of 10×10), 30s, or Bulk HDPE Jars of 1000s (Institutional Packs).
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Tablet (Oral) |
| Packaging | PVC-Alu Blister or Alu-Alu Blister |
| Storage | Store below 25°C. Protect from light. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Cross-Contamination Protocol: Disulfiram is a potent sensitizer. We manufacture it in segregated suites with dedicated HVAC systems to ensure zero cross-contamination with other products.
- Stability: Disulfiram is sensitive to light and degradation. Our formulation utilizes light-resistant excipients and opaque packaging to maintain potency over a 36-month shelf life.
Therapeutic Indications (Human Use)
Indicated for the management of chronic alcoholism:
- Deterrent Therapy: As an aid in the management of selected chronic alcohol patients who want to remain in a state of enforced sobriety so that supportive and psychotherapeutic treatment may be applied.
Dosage & Administration
Recommended Dosage (Strictly as per Psychiatrist):
- Route: Oral.
- Induction Phase: 500 mg once daily for the first 1 to 2 weeks.
- Maintenance Phase: 250 mg daily (range 125 mg to 500 mg) based on tolerance and effectiveness.
- CRITICAL PREREQUISITE: Do not administer until the patient has abstained from alcohol for at least 12 hours. Administering to an intoxicated patient can cause a severe, life-threatening reaction.
- Timing: Can be taken at bedtime if sedation occurs.
Safety Warnings:
- Hidden Alcohol: Patients must be warned to avoid sauces, vinegar, cough syrups, and aftershave lotions that contain alcohol, as these can trigger the reaction.
- Hepatotoxicity: Rare but fatal liver failure has been reported. Baseline and periodic Liver Function Tests (LFTs) are mandatory.
- Cardiac Risk: Use with extreme caution in patients with heart disease, as the hypotension (low blood pressure) during a reaction can cause ischemia.
- Psychosis: Can induce psychotic episodes in patients with a history of mental illness.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
