Description
Etofylline + Theophylline Tablets
Healthy Inc is a specialized global supplier and exporter of synergistic respiratory formulations. We provide high-stability Etofylline + Theophylline Tablets (Prolonged Release / Retard), sourced from WHO–GMP certified solid dosage facilities. This “Dual-Xanthine” bronchodilator is a top export to pulmonology clinics, government dispensaries, and pharmacy chains in Africa, LATAM, and Southeast Asia, serving as a cost-effective cornerstone for the long-term management of Asthma and Chronic Obstructive Pulmonary Disease (COPD).
Product Overview
This formulation combines two methylxanthine derivatives to ensure optimal solubility and sustained bronchodilation.
The “Airway Opener” Specialist:
- Synergy of Solubility: Theophylline is a potent bronchodilator but is poorly soluble in water. Etofylline (a hydroxyethyl derivative) is highly soluble and acts as a solubilizer for Theophylline while contributing its own bronchodilating effects. This combination ensures consistent absorption and bioavailability.
- Mechanism: Both agents inhibit the enzyme Phosphodiesterase (PDE), increasing cyclic AMP (cAMP) levels in bronchial smooth muscle cells. This leads to:
- Bronchodilation: Relaxation of the airways, relieving wheezing and breathlessness.
- Diaphragm Strength: Improved contractility of the diaphragm, reducing respiratory fatigue.
- Mucociliary Clearance: Enhanced clearance of mucus from the lungs.
- Prolonged Release (Retard): Our formulation uses a specialized matrix to release the drugs slowly over 12–24 hours, maintaining therapeutic blood levels without the “peak” spikes that cause nausea and palpitations.
Product Composition & Strength
We supply this product as Prolonged Release (PR/Retard) Tablets or standard Film Coated Tablets.
| Formulation Variant | Etofylline Strength | Theophylline Strength | Total Potency | Role |
|---|---|---|---|---|
| Standard Tablet | 77 mg | 23 mg | 100 mg | Acute / Pediatric |
| Retard 150 | 115 mg | 35 mg | 150 mg | Mild Maintenance |
| Retard 300 | 231 mg | 69 mg | 300 mg | Adult Standard (BID) |
| Retard 450 | 346.5 mg | 103.5 mg | 450 mg | High Dose (OD) |
*Pack Sizes: Blister packs of 10s (Box of 10×10), 15s, 30s, or Bulk HDPE Jars of 1000s.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Tablet (Prolonged Release) |
| Packaging | PVC-Alu Blister or Alu-Alu Blister |
| Storage | Store below 25°C. Protect from moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Release Profile Control: Methylxanthines have a narrow therapeutic index (the difference between a safe dose and a toxic dose is small). Our “Retard” technology ensures zero-order release kinetics, preventing “dose dumping” which can cause severe tachycardia or tremors.
- Assay Precision: We use High-Performance Liquid Chromatography (HPLC) to strictly verify the ratio of Etofylline to Theophylline in every batch, ensuring consistent potency.
Therapeutic Indications (Human Use)
Indicated for the management of reversible airway obstruction:
- Bronchial Asthma: Prevention and treatment of wheezing and shortness of breath.
- COPD (Chronic Obstructive Pulmonary Disease): Chronic bronchitis and emphysema.
- Chronic Bronchospasm: Maintenance therapy to keep airways open during the night (Nocturnal Asthma).
Dosage & Administration
Recommended Dosage (Strictly as per Pulmonologist):
- Route: Oral.
- Standard Tablets (100mg): 1 tablet three times daily (Short acting).
- Retard 300 (Prolonged Release): 1 tablet taken twice daily (every 12 hours).
- Retard 450 (Prolonged Release): 1 tablet once daily (usually in the evening).
- Administration: Swallow whole with water after meals. Do not chew or crush Retard tablets, as this destroys the slow-release mechanism and increases toxicity risk.
Safety Warnings:
- Narrow Therapeutic Window: Theophylline levels must be monitored in long-term users. Toxicity can cause seizures and arrhythmias.
- Caffeine Interaction: Patients should limit intake of coffee, tea, and chocolate, as these are also xanthines and can potentiate side effects like jitteriness and insomnia.
- Smoking: Smoking increases the metabolism of theophylline (makes it clear faster), so smokers may require higher doses. Quitting smoking may require a dose reduction.
- Cardiovascular: Use with caution in patients with cardiac tachyarrhythmias.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
