Description
Imidapril Hydrochloride Tablets
Healthy Inc is a specialized global supplier and exporter of advanced cardiovascular agents. We provide high-purity Imidapril Hydrochloride Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Kidney-Protective” ACE Inhibitor is a top export to diabetic care clinics, cardiology departments, and government health formularies in Africa, LATAM, and Southeast Asia, recognized for its high efficacy in treating hypertension and slowing the progression of renal disease.
[Image of Imidapril mechanism of action inhibition of ACE enzyme]
Product Overview
This formulation contains Imidapril Hydrochloride, a long-acting, non-sulfhydryl Angiotensin-Converting Enzyme (ACE) inhibitor.
The “Metabolic Friendly” Specialist:
- Prodrug Activation: Imidapril is a prodrug. After oral administration, it is rapidly hydrolyzed in the liver to its active metabolite, Imidaprilat.
- Mechanism: Imidaprilat inhibits the ACE enzyme, preventing the conversion of Angiotensin I to Angiotensin II (a potent vasoconstrictor). This leads to:
- Relaxation of blood vessels (Vasodilation).
- Reduction in aldosterone secretion (decreasing sodium and water retention).
- Renal Protection: Unlike some other antihypertensives, Imidapril reduces intraglomerular pressure, making it highly effective in reducing Microalbuminuria (protein leakage) in Type 1 and Type 2 diabetics. It preserves kidney function.
- Lipophilicity: High tissue penetration ensures a sustained 24-hour effect with once-daily dosing.
Product Composition & Strength
We supply this product as Uncoated Tablets (scored for precise titration). The standard strengths are optimized for maintenance therapy.
| Active Ingredient | Strength (Standard) | Role |
|---|---|---|
| Imidapril HCl | 5 mg | Initial Dose / Renal Impairment |
| Imidapril HCl | 10 mg | Standard Maintenance Dose |
| Excipients | Q.S. | Lactose / Macrogol |
*Pack Sizes: Blister packs of 10s (Box of 10×10), 14s (Calendar Pack), or Bulk HDPE Jars of 1000s.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Tablet (Oral) |
| Packaging | Alu-Alu Blister (Moisture Sensitive) |
| Storage | Store below 25°C. Strictly Protect from Moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Hydrolysis Prevention: Imidapril is highly susceptible to hydrolysis (breaking down in humidity). We process it in dehumidified suites (< 30% RH) and package it exclusively in Cold Form Alu-Alu Blisters to guarantee shelf-life stability in tropical climates.
- Bioequivalence: Our formulation matches the dissolution profile of the innovator (Tanatril), ensuring consistent conversion to Imidaprilat in the liver.
Therapeutic Indications (Human Use)
Indicated for the management of cardiovascular and renal conditions:
- Essential Hypertension: Treatment of mild to moderate high blood pressure.
- Diabetic Nephropathy: Indicated for Type 1 diabetics with macroalbuminuria to slow the progression of renal insufficiency.
Dosage & Administration
Recommended Dosage (Strictly as per Cardiologist/Nephrologist):
- Route: Oral.
- Adults (Hypertension): Initially 5 mg once daily. If optimal blood pressure is not achieved after 3 weeks, the dose may be increased to 10 mg daily.
- Renal Impairment: In patients with reduced kidney function (CrCl 30-80 ml/min), the starting dose should be reduced to 2.5 mg once daily.
- Timing: Should be taken about 15 minutes before meals (food may slightly reduce absorption, but consistency is key).
Safety Warnings:
- Dry Cough: A persistent, non-productive cough is a common class effect of all ACE inhibitors (due to bradykinin accumulation).
- Angioedema: Rare but life-threatening swelling of the face, lips, or throat. Discontinue immediately if observed.
- Hyperkalemia: Inhibits aldosterone, leading to potassium retention. Monitor serum potassium levels, especially if used with potassium-sparing diuretics.
- Pregnancy (Black Box): Contraindicated in pregnancy. Can cause fetal injury and death.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
