Description

Isosorbide Tablets (Dinitrate & Mononitrate)

Healthy Inc is a premier global provider of chronic cardiovascular therapies. We provide premium Isosorbide Tablets, including Isosorbide Dinitrate (ISDN) and Isosorbide Mononitrate (ISMN), manufactured in WHO–GMP certified specialized cardiovascular production units. As the gold standard for long-term prophylaxis of angina pectoris, this product is a vital export for cardiology clinics, geriatric care centers, and Ministry of Health (MOH) tenders in Southeast Asia, Africa, and the Middle East.

Product Overview

Isosorbide is a potent organic nitrate vasodilator. While Isosorbide Dinitrate is used for both acute and chronic management, Isosorbide Mononitrate—the active metabolite of the dinitrate—is specifically engineered for high oral bioavailability and long-term maintenance therapy to prevent chest pain.

The “Vascular Relief” Specialist:

• Mechanism of Action: Isosorbide acts as a source of Nitric Oxide (NO). NO stimulates the enzyme guanylate cyclase, increasing intracellular cGMP, which leads to the dephosphorylation of the myosin light chain and subsequent vascular smooth muscle relaxation.
• Hemodynamic Impact: By inducing systemic venous and arterial dilation, it significantly reduces left ventricular end-diastolic pressure (preload) and systemic vascular resistance (afterload), thereby decreasing myocardial oxygen demand.
• Bioavailability (Mononitrate): Unlike the Dinitrate, Isosorbide Mononitrate is not subject to first-pass hepatic metabolism, resulting in nearly 100% bioavailability and highly predictable plasma levels.

Technical & Manufacturing Specifications

Formulated for immediate and sustained release to prevent “Nitrate Tolerance.”

Manufacturing Authority

Marketed and Distributed by Healthy Inc from ISO 9001:2015 certified units.

• Explosive API Handling: Isosorbide Dinitrate is chemically related to explosives. Our facilities utilize specialized diluted API handling protocols (diluted with lactose or mannitol) to ensure safety during the formulation and compression stages.
• Controlled Release Precision: Our SR (Sustained Release) variants utilize a multi-unit pellet system or matrix technology to ensure a “Nitrate-Free Interval,” which is clinically essential to prevent pharmacological tolerance.
• Stability Validation: Validated for Zone IVb climates. Organic nitrates are sensitive to environmental factors; our specialized primary packaging ensures 36-month stability in tropical regions.

Therapeutic Indications & Clinical Symptoms

• Angina Pectoris: Long-term prophylaxis and treatment of chronic stable angina.
• Congestive Heart Failure: Adjunctive therapy in chronic heart failure management (often in combination with Hydralazine).
• Esophageal Achalasia: Occasionally used to relax the lower esophageal sphincter.

Dosage & Administration

• Isosorbide Mononitrate: Typically 20 mg twice daily, with doses taken 7 hours apart (e.g., 8 AM and 3 PM) to maintain a nitrate-free interval at night.
• Safety Note: Do not use with PDE5 inhibitors (Sildenafil, Tadalafil) due to the risk of severe, life-threatening hypotension. Common side effects include “Nitrate Headache” and postural hypotension.

Global Export & Contract Manufacturing Services

Healthy Inc is a verified Cardiovascular Exporter in Mumbai, catering to Specialty Cardiology Hospitals and Ministry of Health Tenders. We offer Third Party Manufacturing for Isosorbide Tablets with full CTD Dossier and COPP support. Our logistics network ensures secure transit to Vietnam, Nigeria, UAE, and the Philippines, providing WHO-GMP quality at competitive B2B prices.

Commercial Inquiries

WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in