Description
Losartan Potassium Tablets (25 mg / 50 mg / 100 mg)
Healthy Inc is a specialized global supplier of high-stability Angiotensin II Receptor Blockers (ARBs). We provide premium Losartan Potassium Tablets, manufactured in WHO–GMP certified solid dosage facilities. As a first-in-class ARB for hypertension and diabetic nephropathy, this product is a primary export for nephrology centers, cardiology units, and government health ministries across Africa, Southeast Asia, and LATAM.
Product Overview
Losartan Potassium is a synthetic, potent, and orally active non-peptide antagonist of the Angiotensin II receptor (Type AT1). It is engineered to provide precise blood pressure regulation and significant end-organ protection.
The “Renoreceptor” Specialist:
- Mechanism of Action: Losartan selectively blocks the binding of Angiotensin II to the AT1 receptor found in many tissues, such as vascular smooth muscle and the adrenal gland. Unlike ACE inhibitors, Losartan does not inhibit the breakdown of bradykinin, significantly reducing the incidence of dry cough while providing potent vasodilation.
- Active Metabolite Synergy: Losartan is partially converted by the liver into a 10-to-40 times more potent carboxylic acid metabolite (E-3174), which is responsible for the majority of the drug’s long-acting antihypertensive effect, ensuring consistent 24-hour control.
- Uricosuric Properties: Unique among ARBs, Losartan promotes the excretion of uric acid, making it a preferred choice for hypertensive patients with concurrent hyperuricemia or gout.
Technical & Manufacturing Specifications
Formulated for high solubility and robust stability in tropical environmental zones.
| Technical Metric | Specification Standard |
|---|---|
| Active Ingredient | Losartan Potassium BP / USP / IP |
| Solubility | Freely soluble in water (Ensures rapid absorption) |
| HS Code | 3004.90.99 (Cardiovascular Antihypertensives) |
| Packaging | Alu-Alu Blister (Hygroscopic protection) |
| Storage | Store below 30°C. Protect from moisture and light. |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from ISO 9001:2015 certified units.
- Hygroscopicity Management: Losartan Potassium is highly sensitive to moisture. Our facility utilizes Relative Humidity (RH) controlled cleanrooms (<35%) and cold-form Alu-Alu packaging to ensure tablet hardness and molecular integrity.
- Dissolution Precision: We conduct rigorous comparative dissolution profiling at pH 1.2, 4.5, and 6.8 to ensure bioequivalence with the innovator brand (Cozaar), facilitating seamless clinical transition.
- Advanced Coating: Our tablets are finished with a moisture-barrier film coating (Opadry®) to enhance stability and ensure the medication remains stable in hot and humid (Zone IVb) climates.
Therapeutic Indications & Clinical Symptoms
- Hypertension: First-line treatment for high blood pressure to reduce cardiovascular mortality.
- Diabetic Nephropathy: Renal protection in Type 2 diabetic patients with proteinuria and hypertension.
- Stroke Risk Reduction: Indicated for hypertensive patients with Left Ventricular Hypertrophy (LVH).
- Heart Failure: Used as an alternative for patients intolerant to ACE inhibitors.
Dosage & Administration
- Administration: Typically once daily, with or without food.
- Dosing: Standard starting dose is 50 mg, which may be increased to 100 mg based on clinical response.
- Contraindications: Absolutely contraindicated during pregnancy (second and third trimesters) due to fetal renal toxicity.
Global Export & Contract Manufacturing Services
Healthy Inc is a verified Pharmaceutical Exporter in Mumbai, catering to Ministry of Health Tenders and private cardiology wholesalers. We offer Third Party Manufacturing for Losartan with customized strengths and private labeling. Our logistics network facilitates bulk supply to Vietnam, Philippines, Nigeria, and LATAM, ensuring WHO-GMP quality at competitive B2B prices.
Commercial Inquiries
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
