Description
Nevirapine Tablets (200 mg)
Healthy Inc is a premier global provider of high-potency antiretroviral therapies. We provide premium Nevirapine Tablets, manufactured in WHO–GMP certified specialized HIV/AIDS production blocks. As a cornerstone of first-line Antiretroviral Therapy (ART), this product is a vital export for HIV/AIDS clinics, specialized research hospitals, and Ministry of Health (MOH) tenders in Sub-Saharan Africa, Southeast Asia, and the Caribbean.
Product Overview
Nevirapine is a potent and highly selective Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) of the dipyridodiazepinone chemical class. It is specifically engineered to halt the replication of the Human Immunodeficiency Virus Type 1 (HIV-1) by directly binding to the reverse transcriptase enzyme.
The “Viral Suppression” Specialist:
- Mechanism of Action: Nevirapine binds non-competitively to the HIV-1 Reverse Transcriptase (RT) at a site adjacent to the catalytic pocket. This binding induces a conformational change in the enzyme, effectively “locking” it and preventing the conversion of viral RNA into DNA.
- PMTCT Gold Standard: Nevirapine is globally recognized for its efficacy in Preventing Mother-to-Child Transmission (PMTCT). A single dose administered to the mother and the newborn significantly reduces the risk of HIV transmission during labor and delivery.
- Synergistic ART: Often utilized in combination with nucleoside analogs (like Zidovudine and Lamivudine), Nevirapine helps achieve undetectable viral loads and facilitates immune system recovery (CD4 count increase).
Technical & Manufacturing Specifications
Formulated for precise dosing and absolute molecular integrity.
| Technical Metric | Specification Standard |
|---|---|
| Active Ingredient | Nevirapine Anhydrous BP / USP / IP |
| Dosage Form | Immediate Release Tablets |
| Standard Strength | 200 mg |
| HS Code | 3004.90.99 (Antiretroviral Medicaments) / 2933.99.00 |
| Packaging | HDPE Bottles with Child-Resistant Caps or Alu-Alu Blisters |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from ISO 9001:2015 certified units.
- Purity Assurance: Antiretroviral therapy requires life-long adherence. Our manufacturing process utilizes advanced HPLC impurity profiling to ensure every tablet is free from related substances that could interfere with long-term safety.
- Stability Validation: Validated for Climatic Zone IVb. Our formulation is designed to resist degradation in tropical climates, ensuring the drug maintains its 36-month shelf life in the world’s most affected regions.
- Dissolution Precision: We ensure 100% batch-to-batch consistency in dissolution rates, providing predictable bioavailability and preventing “viral escape” caused by fluctuating blood levels.
Therapeutic Indications & Clinical Symptoms
- HIV-1 Infection: Treatment of HIV-1 infected adults and children in combination with other antiretroviral agents.
- PMTCT: Prevention of vertical transmission of HIV-1 from mother to child.
- Post-Exposure Prophylaxis (PEP): Used in certain high-risk occupational or non-occupational exposure regimens.
Dosage & Administration
- Adult Lead-in Phase: A critical 14-day lead-in period of 200 mg once daily is required to reduce the frequency of skin rash, followed by 200 mg twice daily.
- Pediatric Dosing: Based on body surface area or weight.
- Safety Note: Monitor closely for Hepatotoxicity and severe skin reactions (SJS/TEN). If a severe rash occurs, therapy must be permanently discontinued.
Global Export & Contract Manufacturing Services
Healthy Inc is a verified Antiretroviral Exporter in Mumbai, catering to HIV Specialty Centers and International Relief Tenders. We offer Third Party Manufacturing for Nevirapine with full CTD Dossier and COPP support. Our logistics network ensures secure transit to South Africa, Kenya, Thailand, and the Caribbean, providing WHO-GMP quality at competitive B2B prices.
Commercial Inquiries
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
