Description
Nifedipine Sustained Release Tablets (10 mg / 20 mg)
Healthy Inc is a premier global supplier of high-stability cardiovascular therapies. We provide premium Nifedipine Sustained Release (SR) Tablets, manufactured in WHO–GMP certified specialized solid dosage units. As a critical agent for the long-term management of hypertension and chronic stable angina, this product is a vital export for cardiology centers, geriatric care providers, and Ministry of Health (MOH) tenders in Southeast Asia, Africa, and the Middle East.
Product Overview
Nifedipine is a potent dihydropyridine calcium channel blocker. Our Sustained Release (SR) formulation is specifically engineered to overcome the rapid peaks and troughs associated with immediate-release Nifedipine, providing a smooth, consistent plasma concentration that reduces the risk of reflex tachycardia.
The “Consistent Pressure Control” Specialist:
- Mechanism of Action: Nifedipine inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. By specifically targeting the L-type calcium channels, it induces systemic vasodilation, thereby reducing peripheral vascular resistance and lowering arterial blood pressure.
- Anti-Anginal Efficacy: By dilating the main coronary arteries and systemic arterioles, Nifedipine increases myocardial oxygen delivery while simultaneously decreasing the myocardial oxygen demand (afterload).
- SR Delivery Technology: Our tablets utilize a matrix-controlled release system. This ensures the drug is released gradually over several hours, maintaining therapeutic efficacy and allowing for simplified twice-daily or once-daily dosing regimens.
Technical & Manufacturing Specifications
Formulated for precise release kinetics and long-term molecular stability.
| Technical Metric | Specification Standard |
|---|---|
| Active Ingredient | Nifedipine BP / USP / IP |
| Dosage Form | Sustained Release (SR) / Extended Release (ER) Tablets |
| Available Strengths | 10 mg, 20 mg, 30 mg, 60 mg |
| HS Code | 3004.90.69 (Antihypertensives) / 2933.39.19 |
| Packaging | Alu-Alu Blister (Highly light and moisture sensitive) |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from ISO 9001:2015 certified units.
- Light-Sensitive Handling: Nifedipine is highly photosensitive. Our manufacturing occurs in UV-protected cleanrooms with amber-colored processing equipment to ensure zero degradation of the active molecule.
- Matrix Integrity: We utilize specialized hydrophilic polymers to create the sustained-release matrix, ensuring that the tablet does not “dose dump” even in varying gastric pH levels.
- Stability Validation: Validated for Zone IVb (40°C / 75% RH). Our tablets utilize high-barrier Alu-Alu foils to maintain the integrity of the SR coating in tropical export markets.
Therapeutic Indications & Clinical Symptoms
- Hypertension: Long-term management of high blood pressure to prevent stroke and renal failure.
- Chronic Stable Angina: Prevention of chest pain associated with coronary artery disease.
- Vasospastic (Prinzmetal’s) Angina: Treatment of angina caused by coronary artery spasms.
- Raynaud’s Phenomenon: Off-label use for the management of digital vasospasms.
Dosage & Administration
- Administration: Tablets must be swallowed whole. Do not crush, chew, or break the SR tablet, as this destroys the sustained-release mechanism.
- Dosing: Usually 10 mg to 20 mg twice daily, or as directed by a cardiologist.
- Safety Note: Avoid grapefruit juice, as it can significantly increase Nifedipine plasma levels. Common side effects include peripheral edema (ankle swelling), headache, and flushing.
Global Export & Contract Manufacturing Services
Healthy Inc is a verified Cardiovascular Exporter in Mumbai, catering to International Pharmacy Chains and Ministry of Health Tenders. We offer Third Party Manufacturing for Nifedipine SR with full CTD Dossier and COPP support. Our logistics network ensures secure transit to Vietnam, Nigeria, UAE, and the Philippines, providing WHO-GMP quality at competitive B2B prices.
Commercial Inquiries
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
