Description
Pentoxifylline Sustained-Release Tablets (400 mg)
Healthy Inc is a specialized global supplier of high-stability vascular and hemorheological therapies. We provide premium Pentoxifylline Tablets, primarily in Sustained-Release (SR) formulations, manufactured in WHO–GMP certified facilities. As a critical agent for peripheral vascular disease, this product is a primary export for vascular surgery centers, diabetic clinics, and geriatric hospitals in Southeast Asia, Africa, and the CIS region.
Product Overview
Pentoxifylline is a xanthine derivative. Unlike traditional vasodilators, it is classified as a hemorheological agent, specifically engineered to improve blood flow by modifying the rheological properties of blood rather than simply dilating blood vessels.
The “Blood Flow Optimizer” Specialist:
- Mechanism of Action: Pentoxifylline improves erythrocyte deformability (the ability of red blood cells to change shape). It increases intracellular ATP levels in RBCs, allowing them to navigate through narrowed capillaries more effectively.
- Viscosity Reduction: It reduces blood viscosity by lowering plasma fibrinogen concentrations and inhibiting the aggregation of platelets and white blood cells (leukocytes).
- Enhanced Oxygenation: By improving microcirculation, it enhances tissue oxygenation in patients with chronic peripheral arterial disease, leading to a significant increase in pain-free walking distance.
Technical & Manufacturing Specifications
Formulated for controlled release to maintain optimal hemorheological effects.
| Technical Metric | Specification Standard |
|---|---|
| Active Ingredient | Pentoxifylline BP / USP / IP |
| Dosage Form | Sustained-Release (SR) Film-Coated Tablets |
| Standard Strength | 400 mg |
| HS Code | 3004.90.99 (Medicaments) / 2933.99.90 |
| Stability | Validated for Zone IVb (Tropical) export climates |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from ISO 9001:2015 certified units.
- Controlled-Release Matrix: Pentoxifylline has a short half-life. Our tablets utilize a specialized hydrophilic matrix system that releases the drug slowly over 12 hours, ensuring steady-state plasma levels and minimizing gastrointestinal side effects.
- Dissolution Precision: Every batch is subjected to rigorous comparative dissolution profiling to ensure it matches the release kinetics of the innovator brand (Trental).
- High Purity Standards: We monitor strictly for related xanthine impurities and residual solvents, ensuring a safe profile for long-term use in elderly populations with multiple comorbidities.
Therapeutic Indications & Clinical Symptoms
- Intermittent Claudication: Treatment of peripheral potential arterial disease to improve walking distance and reduce leg pain/cramping.
- Diabetic Angiopathy: Management of circulatory disorders associated with diabetes.
- Venous Leg Ulcers: Adjunctive therapy to improve healing rates in chronic venous insufficiency.
- Cerebrovascular Disorders: Management of symptoms related to impaired cerebral blood flow (off-label/adjunct).
Dosage & Administration
- Standard Dose: One 400 mg SR tablet three times daily.
- Administration: Tablets must be swallowed whole with meals to reduce gastric upset; do not crush or chew.
- Clinical Response: Maximum therapeutic benefit may take 2 to 4 weeks of continuous treatment to manifest.
Global Export & Contract Manufacturing Services
Healthy Inc is a verified Pharmaceutical Exporter in Mumbai, catering to Vascular Hospital Chains and Ministry of Health Tenders. We offer Third Party Manufacturing for Pentoxifylline SR with full CTD Dossier and COPP support. Our logistics network ensures streamlined delivery to Vietnam, Nigeria, Philippines, and Uzbekistan, providing WHO-GMP quality at competitive B2B prices.
Commercial Inquiries
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
