Description
Ramipril Tablets
Healthy Inc is a specialized global supplier and exporter of premier cardiovascular protection agents. We provide high-purity Ramipril Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Tissue-Specific” ACE Inhibitor is a top export to cardiology institutes, diabetic care centers, and government health formularies in Africa, LATAM, and Southeast Asia, recognized globally (HOPE Study) for its superior ability to reduce the risk of heart attack, stroke, and death in high-risk patients.
Product Overview
This formulation contains Ramipril, a prodrug that metabolizes into the active ACE inhibitor, Ramiprilat.
The “Vascular Protector” Specialist:
- Mechanism: Ramipril inhibits the Angiotensin-Converting Enzyme (ACE). This stops the conversion of Angiotensin I to Angiotensin II (a potent vasoconstrictor). The result is relaxed blood vessels and lower blood pressure.
- Tissue Affinity (The Difference): Unlike older ACE inhibitors (like Enalapril), Ramipril is highly lipophilic and has a high affinity for tissue ACE found in the heart, kidneys, and blood vessels. This allows it to protect these organs directly, beyond just lowering blood pressure.
- Renal Protection: It is the gold standard for slowing the progression of kidney disease (nephropathy) in both diabetic and non-diabetic patients by reducing glomerular pressure.
Product Composition & Strength
We supply this product as Uncoated Tablets (White/Yellow, scored). The wide range of strengths supports the “Start Low, Go Slow” titration protocol.
| Active Ingredient | Strength (Standard) | Primary Role |
|---|---|---|
| Ramipril USP/BP | 1.25 mg | Initiation (Renal/Diuretic Patients) |
| Ramipril USP/BP | 2.5 mg | Standard Start Dose |
| Ramipril USP/BP | 5 mg | Standard Maintenance |
| Ramipril USP/BP | 10 mg | Target Dose (CV Risk Reduction) |
*Pack Sizes: Alu-Alu Blister packs of 10s (Box of 10×10), 14s, 28s (Calendar Pack), or Bulk HDPE Jars.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| CAS Number | 87333-19-5 |
| Dosage Form | Tablet (Oral) |
| Packaging | Alu-Alu Blister (Highly Moisture/Stress Sensitive) |
| Storage | Store below 25°C. Protect from Moisture and Heat. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Stability Engineering: Ramipril is chemically unstable and prone to degradation into diketopiperazine (DKP) and Ramipril diacid if exposed to moisture or mechanical stress (compression heat). We use low-shear granulation and Cold Form Alu-Alu packaging to ensure impurity levels remain below ICH limits throughout the shelf life.
- Prodrug Conversion: Formulated to ensure consistent absorption and hepatic conversion to Ramiprilat, providing a predictable onset of action.
Therapeutic Indications (Human Use)
Indicated for cardiovascular risk reduction and treatment:
- Hypertension: Monotherapy or combination with thiazide diuretics.
- Heart Failure (Post-MI): Treatment of patients after a heart attack who have signs of heart failure (improves survival).
- Cardiovascular Risk Reduction: Prevention of myocardial infarction, stroke, or cardiovascular death in patients >55 years with high risk (history of CAD, stroke, or PAD).
- Diabetic Nephropathy: Treatment of kidney disease to reduce protein in urine (microalbuminuria).
Dosage & Administration
Recommended Dosage (Strictly as per Cardiologist):
- Route: Oral.
- Hypertension: Start 2.5 mg once daily. Titrate to 5 mg or 10 mg based on response.
- CV Risk Reduction (HOPE Protocol): Start 2.5 mg daily for 1 week, then 5 mg for 3 weeks, then increase to 10 mg once daily (Target Dose).
- Post-MI / Heart Failure: Start very low (1.25 mg or 2.5 mg twice daily). Titrate to target 5 mg twice daily.
- Administration: Swallow whole with liquid. Can be taken with or without food.
Safety Warnings:
- Dry Cough: A persistent, dry, hacking cough is a common class effect of ACE inhibitors (due to bradykinin accumulation). If intolerable, switch to an ARB.
- Pregnancy (Black Box Warning): Strictly Contraindicated. Causes fetal injury and death (oligohydramnios). Stop immediately if pregnancy is detected.
- Hyperkalemia: Increases potassium levels. Monitor electrolytes, especially if taking potassium supplements or Spironolactone.
- Angioedema: Rare but fatal swelling of the face/throat. Emergency attention required.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
