Description
Trihexyphenidyl Hydrochloride Tablets
Healthy Inc is a specialized global supplier and exporter of antiparkinsonian agents. We provide high-purity Trihexyphenidyl Hydrochloride Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Anticholinergic Stabilizer” is a top export to psychiatric wards, neurology centers, and government formularies in Africa, LATAM, and Southeast Asia, serving as a primary adjunct therapy for Parkinson’s disease and a critical antidote for drug-induced movement disorders.
Product Overview
This formulation contains Trihexyphenidyl Hydrochloride (also known as Benzhexol), a synthetic antispasmodic drug.
The “Tremor & Rigidity” Specialist:
- Mechanism of Action: It acts by blocking acetylcholine receptors in the central nervous system (CNS). In Parkinson’s disease, there is an imbalance between dopamine (low) and acetylcholine (high). Trihexyphenidyl restores this balance by lowering cholinergic activity.
- EPS Control: It is the standard treatment for Extrapyramidal Symptoms (EPS)—severe muscle spasms, restlessness (akathisia), and rigidity caused by antipsychotic medications (e.g., Haloperidol, Chlorpromazine).
- Sialorrhea Management: Effectively controls excessive drooling (sialorrhea), a common and distressing symptom of Parkinsonism.
- Mood Elevation: Clinicians often note a mild euphoric or mood-lifting effect, which helps combat the depression associated with chronic motor disorders.
Product Composition & Strength
We supply this product as Uncoated Tablets. The tablets are often scored to allow for precise titration.
| Active Ingredient | Strength (Standard) | Role |
|---|---|---|
| Trihexyphenidyl HCl USP/BP | 2 mg | Initial Dose / EPS Prophylaxis |
| Trihexyphenidyl HCl USP/BP | 5 mg | Maintenance Dose / High Potency |
| Excipients | Q.S. | Binder / Filler |
*Pack Sizes: Blister packs of 10s, 15s, or Bulk HDPE Jars of 1000s (Hospital Packs).
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Tablet (Oral) |
| Packaging | PVC-Alu Blister or Alu-Alu Blister |
| Storage | Store below 30°C. Protect from light. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Hardness & Friability: Trihexyphenidyl tablets are often dispensed in bulk jars for hospital use. We manufacture them with high compression force to ensure they do not crumble during transport, while still passing standard disintegration tests (DT < 15 mins).
- Assay Stability: The HCl salt is stable, but we ensure precise blending uniformity as the therapeutic window is narrow (preventing overdose toxicity).
Therapeutic Indications (Human Use)
Indicated for the management of movement disorders:
- Parkinsonism: Adjunctive therapy in all forms of parkinsonism (post-encephalitic, arteriosclerotic, and idiopathic).
- Drug-Induced EPS: Control of extrapyramidal disorders (acute dystonic reactions, akathisia) caused by central nervous system drugs such as phenothiazines and thioxanthenes.
Dosage & Administration
Recommended Dosage (Strictly as per Neurologist/Psychiatrist):
- Route: Oral.
- Initial Dose: 1 mg to 2 mg per day.
- Titration: Dose is increased by 2 mg increments at intervals of 3 to 5 days.
- Maintenance: Usually 5 mg to 15 mg daily in divided doses (3 times a day).
- Timing: Best taken with food to minimize gastric irritation. If dry mouth is excessive, take before meals.
Safety Warnings:
- Anticholinergic Toxicity: Overdose causes “Hot as a hare, dry as a bone, blind as a bat, red as a beet, mad as a hatter” (Hyperthermia, Dry mouth, Blurred vision, Flushing, Confusion).
- Geriatric Use: Elderly patients are highly sensitive and may develop confusion or hallucinations. Use lower doses.
- Contraindication: Do not use in patients with Narrow-Angle Glaucoma.
- Withdrawal: Do not stop abruptly; may cause exacerbation of parkinsonism or Neuroleptic Malignant Syndrome (NMS).
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
