Description
Clopidogrel Tablets
Healthy Inc is a specialized global supplier and exporter of life-saving anti-thrombotic agents. We provide high-purity Clopidogrel Bisulfate Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Gold Standard” Antiplatelet is a top export to interventional cardiology centers, cath labs, and stroke units in Africa, LATAM, and Southeast Asia, serving as the critical preventative therapy for patients with Acute Coronary Syndrome (ACS) and those undergoing angioplasty (stenting).
Product Overview
This formulation contains Clopidogrel Bisulfate, a thienopyridine class antiplatelet agent.
The “Stent Guardian” Specialist:
- Mechanism (P2Y12 Inhibition): Clopidogrel is a prodrug. Once swallowed, it is metabolized by the liver (specifically CYP2C19 enzymes) into its active form. This active metabolite irreversibly binds to the P2Y12 class of ADP receptors on the platelet surface.
- The “Sticky” Blocker: By blocking these receptors, it prevents Adenosine Diphosphate (ADP) from activating the platelets. This stops platelets from clumping together to form dangerous blood clots (thrombi).
- Irreversible Action: The effect lasts for the entire lifespan of the platelet (7–10 days). Normal platelet function is restored only as new platelets are generated by the body.
- Stent Protection: It is the primary drug used (often with Aspirin) to prevent “Stent Thrombosis”—a fatal complication where a clot forms inside a newly placed cardiac stent.
Product Composition & Strength
We supply this product as Film Coated Tablets (usually Pink or Red). We offer both the standard maintenance dose and the high-dose loading unit.
| Active Ingredient | Strength (Standard) | Primary Role |
|---|---|---|
| Clopidogrel Bisulfate USP/BP | 75 mg | Daily Maintenance |
| Clopidogrel Bisulfate USP/BP | 300 mg | Emergency Loading Dose |
| Excipients | Q.S. | Mannitol / Hydrogenated Castor Oil |
*Pack Sizes: Alu-Alu Blister packs of 10s (Box of 10×10), 14s, 28s (Calendar Pack), or Bulk HDPE Jars.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Film Coated Tablet (Oral) |
| Packaging | Alu-Alu Blister (Hydrolysis Sensitive) |
| Storage | Store below 25°C. Strictly Protect from Moisture. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Polymorph Control: Clopidogrel Bisulfate exists in two crystal forms. Form I is kinetically unstable. We strictly utilize Polymorph Form II, which is thermodynamically stable, ensuring the drug does not degrade or change crystal structure during shelf storage.
- Hydrolysis Protection: The bisulfate salt is extremely sensitive to moisture and humidity (hygroscopic). We manufacture in low-humidity suites and use Cold Form Alu-Alu blisters to prevent hydrolysis, which produces degradation impurities (Clopidogrel acid).
Therapeutic Indications (Human Use)
Indicated for the prevention of atherothrombotic events:
- Acute Coronary Syndrome (ACS): For patients with Unstable Angina or Non-ST-segment elevation MI (Heart Attack).
- Recent MI or Stroke: Secondary prevention of new ischemic events.
- Peripheral Artery Disease (PAD): Prevention of clots in patients with established PAD.
- Atrial Fibrillation: In patients who cannot take Vitamin K antagonists (Warfarin).
Dosage & Administration
Recommended Dosage (Strictly as per Cardiologist):
- Route: Oral.
- Loading Dose (Emergency): 300 mg (4 tablets of 75mg or 1 tablet of 300mg) taken immediately upon admission for ACS.
- Maintenance Dose: 75 mg once daily.
- Combination: Often taken with low-dose Aspirin (Dual Antiplatelet Therapy – DAPT) for up to 12 months after stent placement.
- Timing: Can be taken with or without food.
Safety Warnings:
- Bleeding Risk: The most significant risk is bleeding. Discontinue 5–7 days before elective surgery to restore platelet function.
- PPI Interaction (CRITICAL): Omeprazole and Esomeprazole inhibit CYP2C19, the enzyme needed to activate Clopidogrel. Taking them together makes Clopidogrel ineffective. Pantoprazole is the preferred safe alternative.
- Poor Metabolizers: Some patients genetically lack CYP2C19 enzymes (“Non-responders”) and may require alternative drugs like Ticagrelor.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
